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Base-edited CAR T-cell therapy shows promise for relapsed, refractory childhood ALL

T-Cells Work to Fight Cancer

Base-edited chimeric antigen receptor T-cell therapy is feasible for the treatment of relapsed or refractory childhood T-cell acute lymphoblastic leukemia, suggests research published in The New England Journal of Medicine.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Add-on tofacitinib shows treatment promise in SSc-ILD

The addition of tofacitinib to conventional disease-modifying antirheumatic drugs could help alleviate sclerosis in patients with systemic sclerosis-associated interstitial lung disease, suggests research.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Cortical gyrification a possible early biomarker for PD progression

Researchers have found reductions in cortical gyrifications in patients with newly diagnosed Parkinson’s disease that worsen over time and may therefore serve as a potential biomarker for disease progression.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Early surgery improves survival for children with drug-resistant epilepsy

Study findings highlight the importance of a multidisciplinary comprehensive approach to drug-resistant epilepsy in children, with the consideration of both medical and surgical treatment options.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Pathogenic variants have additive effect on ALS survival

Genetic variants that modify survival in amyotrophic lateral sclerosis (ALS) can act on their own or in unison, having an additive effect and significantly worsening a patient’s outcome, researchers report in the journal Neurology.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Urinary DKK3 signals declining kidney function and treatment response in children

Increased urinary Dickkopf-related protein 3 levels could indicate declining kidney function in children with chronic kidney disease and be a marker of treatment response, report researchers in The Lancet Child and Adolescent Health.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Autoantibodies may identify Sjögren’s syndrome in Ro-negative patients

The use of autoantibody biomarkers could be a feasible way of identifying Sjögren’s syndrome in patients lacking the anti-Ro antibody without the need for a salivary gland lip biopsy, suggests a proof-of-concept study.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.