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Autoantibodies may identify Sjögren’s syndrome in Ro-negative patients

The use of autoantibody biomarkers could be a feasible way of identifying Sjögren’s syndrome in patients lacking the anti-Ro antibody without the need for a salivary gland lip biopsy, suggests a proof-of-concept study.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Intracerebral polio–rhinovirus immunotherapy feasible for paediatric malignant glioma

Intracerebral recombinant polio–rhinovirus immunotherapy is feasible in children and young people with heavily pretreated, high-grade malignant glioma, suggest phase 1b trial findings published in The Lancet Child & Adolescent Health.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Serious infection risk not increased by rituximab and belimumab in SLE

Neither rituximab nor belimumab significantly increase the risk for serious infection in patients with systemic lupus erythematosus compared with the standard of care, researchers report.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Multimodal genome-wide analysis pinpoints hard-to-diagnose developmental disorders

The Deciphering Developmental Disorders study has provided genetic diagnoses for thousands of children with severe developmental disorders in the UK and Ireland, report the investigators in The New England Journal of Medicine.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

α-synuclein seed amplification potential for early Parkinson’s disease diagnosis

An assay for identifying the build-up of the misfolded α-synuclein protein in cerebrospinal fluid could enhance the detection of Parkinson’s disease in the early stages before the onset of motor symptoms, suggests research.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

AAV2 blamed for acute hepatitis outbreak in children

Three papers published in Nature have linked infection with adeno-associated virus 2 to the recent outbreak of acute severe hepatitis in children.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.