Chronic hypercortisolism in CS disrupts circadian genes and rhythmicity of PBMCs
Chronic hypercortisolism in patients with Cushing’s syndrome may disrupt circadian clock genes, which can alter the daily rhythm of immune cell subpopulations beyond remission, suggests research.
Hypertension perseveres from childhood and adolescence to adulthood
High blood pressure or hypertension in childhood or adolescence appears to endure into adulthood, report researchers in findings that support early prevention.
Hypofractionated proton beam therapy regimen feasible for glioblastoma in older patients
A short course of hypofractionated proton beam therapy given alongside temozolomide may offer an improvement in overall survival for patients aged 65 years and older with a new diagnosis of glioblastoma, suggesting findings from a “hypothesis-generating” study.
Routine postoperative imaging may improve pancreatic cancer survival
Research suggests that patients who are invited for routine imaging after pancreatic ductal adenocarcinoma resection have significantly longer overall survival than those who undergo imaging only after the development of symptoms.
Impact of haematological malignancy on pregnancy revealed
Women who are diagnosed with haematological malignancies during pregnancy have similar overall survival to peers diagnosed within a year of their pregnancy ending, indicates research published in The Lancet Haematology.
Adjunctive fasudil ‘considered safe’ for amyotrophic lateral sclerosis
The Rho-associated kinase inhibitor fasudil as an adjunct to riluzole is well tolerated for the treatment of patients with amyotrophic lateral sclerosis, indicate phase 2 findings from the ROCK-ALS study.
European retinoblastoma report shows stabilised incidence, high 5-year survival
The incidence of retinoblastoma in children in Europe stabilised between 2000 and 2013, say EUROCARE-6 Working Group investigators who report high 5-year survival rates in this population.
Fear of recurrence persists for decades among paediatric cancer survivors
A third of adults who survive childhood cancer continue to have a fear of cancer recurrence for decades after their diagnosis, highlights research published in JAMA Network Open.
X chromosome gene locus linked to increased AD risk
SLC9A7 on the X chromosome has been pinpointed as a novel risk locus for Alzheimer’s disease in a genetic meta-analysis of over 1.15 million individuals.
Predictors of MALT lymphoma in Sjögren’s disease characterised
Researchers have identified rheumatoid factor as an early and persistent independent predictor of mucosa-associated lymphoid tissue lymphoma in patients with Sjögren’s disease.
