Polygenic risk score may improve prostate cancer screening
A polygenic risk score could help direct prostate cancer screening towards those at highest risk for the disease, the BARCODE1 investigators report.
CSF tau may flag hippocampal atrophy in new-onset refractory status epilepticus
Elevated total tau in cerebral spinal fluid may indicate initial brain injury in patients with cryptogenic new-onset refractory status epilepticus and predict subsequent hippocampal atrophy, suggest study findings.
Intensive systolic blood pressure control reduces CVD mortality risk in the over 80s
Antihypertensive treatment of patients over the age of 80 years to a target systolic blood pressure below 130 mmHg could significantly reduce their risk of death from cardiovascular disease by 26%, suggests an analysis of NHANES data.
Half-dose apixaban noninferior for preventing recurrent VTE in cancer patients
For patients with active cancer and venous thromboembolism, a reduced dose of apixaban is noninferior to the standard dose for preventing recurrent thromboembolic episodes and significantly reduces the risk of clinically relevant bleeding, report the API-CAT investigators.
‘Accelerated’ onset of aging-related disease highlighted for childhood cancer survivors
Children who survive for at least 5 years after treatment for cancer are 2.7 times more likely to develop one of eight aging-related chronic health conditions before the age of 65 years than members of the general population, US researchers suggest.
Chemoprevention use after TNBC ‘may be reasonable’
Research indicates that women with triple-negative breast cancer might benefit from low-dose tamoxifen to reduce the risk of recurrent or new primary disease.
Mixed results for tetramethylpyrazine nitrone treatment in ALS
Tetramethylpyrazine nitrone does not slow overall functional decline in patients with amyotrophic lateral sclerosis, but it may help retain grip strength and is well tolerated, suggest study findings.
Quantifying high-risk chromosomal aberrations predicts multiple myeloma prognosis
The presence of two or more high-risk chromosomal aberrations in patients with multiple myeloma is associated with an especially poor outcome throughout the disease course, shows research published in the Journal of Clinical Oncology.
Cancer-related PE death increase shown in the USA
US study findings indicate that the incidence of pulmonary embolism-related death in people with cancer rose significantly between 2011 and 2020 despite an overall reduction in age-adjusted cancer diagnoses and cancer-related deaths over the period.
Larotrectinib discontinuation possible for some paediatric NTRK fusion-positive tumours
Children who respond to larotrectinib therapy for sarcoma with a neurotrophic tyrosine receptor kinase gene fusion may be able to discontinue treatment, indicates research published in the Journal of Clinical Oncology.