OS benefits with perioperative FLOT for resectable oesophageal cancer
Perioperative chemotherapy with fluorouracil, leucovorin, oxaliplatin and docetaxel offers better overall survival than preoperative chemoradiotherapy for patients with locally advanced oesopahgeal adenocarcinoma, the ESOPEC trial investigators report.
Adding targeted therapy to TACE improves PFS for unresectable nonmetastatic liver cancer
Progression-free survival findings from two phase 3 clinical trials support the use of targeted therapies in combination with transarterial chemoembolisation for the treatment of patients with unresectable, nonmetastatic hepatocellular carcinoma.
Adjuvant radiation may preserve HRQoL for low-risk breast cancer patients aged 70+
Two-year interim findings from the EUROPA trial indicate that radiotherapy after surgery for low-risk early breast cancer may be better for preserving health-related quality of life for women aged 70 years and older than endocrine therapy.
Hypertension risk assessment may be improved by ECG-based AI
Research suggests that an electrocardiography-based artificial intelligence risk estimator for hypertension may help to identify patients with an increased risk of developing hypertension and its related adverse outcomes.
Primary MMR deficiency ‘underdiagnosed’ among young people with glioma
Primary mismatch repair deficiency in gliomas is underdiagnosed among people younger than 40 years old, say investigators who recommend assessment of the biomarker to help facilitate checkpoint inhibitor therapy.
Polygenic risk score predicts Gleason upgrading during active surveillance
A polygenic risk score may help to identify patients undergoing active surveillance for clinically localised prostate cancer who are at particular risk of an increase in their Gleason grade, US research shows.
Omitting axillary biopsy ‘noninferior’ for early-stage breast cancer survival
For women undergoing breast-conserving surgery for invasive breast cancer, omission of axillary sentinel lymph node biopsy offers noninferior 5-year invasive disease-free survival compared with standard axillary surgery, say the INSEMA trial investigators.
Striatum microstructural damage linked to disability and cognitive impairment in ALS
Researchers have identified microstructural damage to the striatum in patients with sporadic amyotrophic lateral sclerosis that could play a key role in the motor disability and cognitive deficits associated with the condition.
Chronic hypercortisolism in CS disrupts circadian genes and rhythmicity of PBMCs
Chronic hypercortisolism in patients with Cushing’s syndrome may disrupt circadian clock genes, which can alter the daily rhythm of immune cell subpopulations beyond remission, suggests research.
Hypertension perseveres from childhood and adolescence to adulthood
High blood pressure or hypertension in childhood or adolescence appears to endure into adulthood, report researchers in findings that support early prevention.
