Intracerebral polio–rhinovirus immunotherapy feasible for paediatric malignant glioma

Intracerebral recombinant polio–rhinovirus immunotherapy is feasible in children and young people with heavily pretreated, high-grade malignant glioma, suggest phase 1b trial findings published in The Lancet Child & Adolescent Health.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Anthracycline heart failure risk quantified for breast cancer, lymphoma patients

Patients who receive an anthracycline during treatment for breast cancer or lymphoma are more than three times as likely to develop congestive heart failure than healthy individuals, indicates a case–control study published in JAMA Network Open.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

iNTEGRATE fails to demonstrate significant cGVHD benefit for ibrutinib–prednisone regimen

Combining ibrutinib and prednisone for the treatment of new-onset chronic graft-versus-host disease after allogeneic haematopoietic cell transplantation does not improve patient response compared with prednisone alone, show phase 3 trial findings published in the Journal of Clinical Oncology.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

Sotorasib demonstrates potential for KRAS-mutated pancreatic cancer

The KRAS G12C inhibitor sotorasib has shown “promising anticancer activity” in a phase 1/2 trial of patients with heavily pretreated, metastatic pancreatic cancer harbouring the target mutation, researchers report in The New England Journal of Medicine.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

CT brain cancer risk quantified for children and young adults

The European EPI-CT study has confirmed there is a linear dose–response relationship between radiation exposure during computed tomography imaging and the risk of malignant brain tumours, in children and young adults.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.