OS benefits with perioperative FLOT for resectable oesophageal cancer

Perioperative chemotherapy with fluorouracil, leucovorin, oxaliplatin and docetaxel offers better overall survival than preoperative chemoradiotherapy for patients with locally advanced oesopahgeal adenocarcinoma, the ESOPEC trial investigators report.
Adding targeted therapy to TACE improves PFS for unresectable nonmetastatic liver cancer

Progression-free survival findings from two phase 3 clinical trials support the use of targeted therapies in combination with transarterial chemoembolisation for the treatment of patients with unresectable, nonmetastatic hepatocellular carcinoma.
Adjuvant radiation may preserve HRQoL for low-risk breast cancer patients aged 70+

Two-year interim findings from the EUROPA trial indicate that radiotherapy after surgery for low-risk early breast cancer may be better for preserving health-related quality of life for women aged 70 years and older than endocrine therapy.
Primary MMR deficiency ‘underdiagnosed’ among young people with glioma

Primary mismatch repair deficiency in gliomas is underdiagnosed among people younger than 40 years old, say investigators who recommend assessment of the biomarker to help facilitate checkpoint inhibitor therapy.
Polygenic risk score predicts Gleason upgrading during active surveillance

A polygenic risk score may help to identify patients undergoing active surveillance for clinically localised prostate cancer who are at particular risk of an increase in their Gleason grade, US research shows.
Omitting axillary biopsy ‘noninferior’ for early-stage breast cancer survival

For women undergoing breast-conserving surgery for invasive breast cancer, omission of axillary sentinel lymph node biopsy offers noninferior 5-year invasive disease-free survival compared with standard axillary surgery, say the INSEMA trial investigators.
Hypofractionated proton beam therapy regimen feasible for glioblastoma in older patients

A short course of hypofractionated proton beam therapy given alongside temozolomide may offer an improvement in overall survival for patients aged 65 years and older with a new diagnosis of glioblastoma, suggesting findings from a “hypothesis-generating” study.
Routine postoperative imaging may improve pancreatic cancer survival

Research suggests that patients who are invited for routine imaging after pancreatic ductal adenocarcinoma resection have significantly longer overall survival than those who undergo imaging only after the development of symptoms.
Impact of haematological malignancy on pregnancy revealed

Women who are diagnosed with haematological malignancies during pregnancy have similar overall survival to peers diagnosed within a year of their pregnancy ending, indicates research published in The Lancet Haematology.
European retinoblastoma report shows stabilised incidence, high 5-year survival

The incidence of retinoblastoma in children in Europe stabilised between 2000 and 2013, say EUROCARE-6 Working Group investigators who report high 5-year survival rates in this population.