Biochemical severity scores may predict post-surgery adrenal insufficiency in MACS
Measuring biochemical severity scores before adrenalectomy in people with mild autonomous cortisol secretion could help to identify those likely to develop adrenal insufficiency, suggest researchers.
Minimally invasive surgery improves antihypertensive management in MACS
Surgery to remove all or part of an adrenal gland can help reduce hypertension in people with unilateral incidentalomas and mild autonomous cortisol secretion, suggest findings from the CHIRACIC study.
Elinzanetant reduces vasomotor symptoms during breast cancer endocrine therapy
The neurokinin-targeted agent elinzanetant significantly improves vasomotor symptoms in women undergoing endocrine therapy for hormone receptor-positive breast cancer, research indicates.
Chronic hypercortisolism in CS disrupts circadian genes and rhythmicity of PBMCs
Chronic hypercortisolism in patients with Cushing’s syndrome may disrupt circadian clock genes, which can alter the daily rhythm of immune cell subpopulations beyond remission, suggests research.
Salivary cortisol shows ‘excellent diagnostic performance’ for adrenal insufficiency
Salivary cortisol may be a suitable alternative to serum cortisol when testing for adrenal insufficiency, suggests research showing high diagnostic accuracy on the cosyntropin test.
Cushing’s syndrome linked to increased cancer risk
Patients with endogenous Cushing’s syndrome have a higher incidence of cancer than the general population, suggests a nationwide cohort study from Taiwan.
Sampling lateralization affects BIPSS accuracy for diagnosing CD
Low lateralization may reduce the diagnostic accuracy of bilateral inferior petrosal sinus sampling for distinguishing Cushing’s disease from ectopic adrenocorticotropic hormone (ACTH) secretory syndrome, suggests a study published in the Journal of the Endocrine Society in March 2024.
Machine learning tool guides ACTH-dependent Cushing’s syndrome diagnosis
Researchers have developed a machine learning tool that could help in the differential diagnosis of adrenocorticotropic hormone-dependent Cushing’s syndrome, potentially avoiding the need for bilateral inferior petrosal sinus sampling.
Autoimmune disease risk increased after surgical remission of Cushing’s disease
Patients with Cushing’s disease who achieve remission following surgery have an increased incidence of autoimmune disease, suggest findings published in the Annals of Internal Medicine in February 2024.
Cushing’s syndrome comorbidities require surveillance beyond remission
Experts emphasize the need for long-term surveillance for all patients with Cushing’s syndrome, after their systematic literature review showed associated comorbidities often continue well beyond remission.