Chronic hypercortisolism in CS disrupts circadian genes and rhythmicity of PBMCs
Chronic hypercortisolism in patients with Cushing’s syndrome may disrupt circadian clock genes, which can alter the daily rhythm of immune cell subpopulations beyond remission, suggests research.
Salivary cortisol shows ‘excellent diagnostic performance’ for adrenal insufficiency
Salivary cortisol may be a suitable alternative to serum cortisol when testing for adrenal insufficiency, suggests research showing high diagnostic accuracy on the cosyntropin test.
Cushing’s syndrome linked to increased cancer risk
Patients with endogenous Cushing’s syndrome have a higher incidence of cancer than the general population, suggests a nationwide cohort study from Taiwan.
Sampling lateralization affects BIPSS accuracy for diagnosing CD
Low lateralization may reduce the diagnostic accuracy of bilateral inferior petrosal sinus sampling for distinguishing Cushing’s disease from ectopic adrenocorticotropic hormone (ACTH) secretory syndrome, suggests a study published in the Journal of the Endocrine Society in March 2024.
Machine learning tool guides ACTH-dependent Cushing’s syndrome diagnosis
Researchers have developed a machine learning tool that could help in the differential diagnosis of adrenocorticotropic hormone-dependent Cushing’s syndrome, potentially avoiding the need for bilateral inferior petrosal sinus sampling.
Autoimmune disease risk increased after surgical remission of Cushing’s disease
Patients with Cushing’s disease who achieve remission following surgery have an increased incidence of autoimmune disease, suggest findings published in the Annals of Internal Medicine in February 2024.
Cushing’s syndrome comorbidities require surveillance beyond remission
Experts emphasize the need for long-term surveillance for all patients with Cushing’s syndrome, after their systematic literature review showed associated comorbidities often continue well beyond remission.
Glucocorticoid withdrawal prevalent and persistent after hypercortisolism surgery
Myalgias and arthralgias are prominent symptoms associated with glucocorticoid withdrawal syndrome following surgical remission of endogenous hypercortisolism, report Irina Bancos, from the Mayo Clinic in Rochester, Minnesota, USA, and colleagues.
Bone fragility management justified for postmenopausal women with MACS
Postmenopausal women with adrenal incidentalomas associated with mild autonomous cortisol secretion have a “considerable fracture burden”, report Guido Di Dalmazi and colleagues.
Age-specific CS differences may complicate diagnosis in older patients
Older adults with Cushing’s syndrome are less likely than younger patients to present with typical symptoms of cortisol excess, report Elena Valass and co-researchers.
