Autoantibodies may identify Sjögren’s syndrome in Ro-negative patients
The use of autoantibody biomarkers could be a feasible way of identifying Sjögren’s syndrome in patients lacking the anti-Ro antibody without the need for a salivary gland lip biopsy, suggests a proof-of-concept study.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Intracerebral polio–rhinovirus immunotherapy feasible for paediatric malignant glioma
Intracerebral recombinant polio–rhinovirus immunotherapy is feasible in children and young people with heavily pretreated, high-grade malignant glioma, suggest phase 1b trial findings published in The Lancet Child & Adolescent Health.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Serious infection risk not increased by rituximab and belimumab in SLE
Neither rituximab nor belimumab significantly increase the risk for serious infection in patients with systemic lupus erythematosus compared with the standard of care, researchers report.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Bone fragility management justified for postmenopausal women with MACS
Postmenopausal women with adrenal incidentalomas associated with mild autonomous cortisol secretion have a “considerable fracture burden”, report Guido Di Dalmazi and colleagues.
Multimodal genome-wide analysis pinpoints hard-to-diagnose developmental disorders
The Deciphering Developmental Disorders study has provided genetic diagnoses for thousands of children with severe developmental disorders in the UK and Ireland, report the investigators in The New England Journal of Medicine.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
α-synuclein seed amplification potential for early Parkinson’s disease diagnosis
An assay for identifying the build-up of the misfolded α-synuclein protein in cerebrospinal fluid could enhance the detection of Parkinson’s disease in the early stages before the onset of motor symptoms, suggests research.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
AAV2 blamed for acute hepatitis outbreak in children
Three papers published in Nature have linked infection with adeno-associated virus 2 to the recent outbreak of acute severe hepatitis in children.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
‘Multihit’ gastric cancer risk from H. pylori plus cancer-predisposing variants
The presence of Helicobacter pylori alongside pathogenic variants in cancer-predisposing genes combine to increase the risk for gastric cancer, report researchers in The New England Journal of Medicine.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Neurodevelopment impairment common in FNAIT regardless of intracranial haemorrhage
Children with foetal neonatal alloimmune thrombocytopenia are at high risk of impaired neurodevelopment, especially if they have experienced intracranial haemorrhage, shows research in The Journal of Pediatrics.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Haplo-SCT plus dinutuximab beta ‘feasible’ for relapsed high-risk neuroblastoma
Children with relapsed, high-risk neuroblastoma may benefit from immunotherapy with dinutuximab beta after haploidentical stem-cell transplantation, investigators write in the Journal of Clinical Oncology.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
