Botulinum toxin A injection may ease base-of-thumb osteoarthritis pain
Intra-articular injection with botulinum toxin A results in clinically meaningful pain reduction for up to 3 months in people with base-of-thumb osteoarthritis, French study findings indicate.
Sotagliflozin effects differ from empagliflozin only at breakfast
The only notable short-term differences in the effects of sotagliflozin and empagliflozin occur in glucose metabolism after breakfast, show findings from a randomized trial.
KEYNOTE-355 shows OS benefit with pembrolizumab–chemo in advanced TNBC
Adding pembrolizumab to chemotherapy significantly improves the overall survival of people with advanced triple-negative breast cancer and a tumoral PD-L1 combined positive score of at least 10, demonstrate phase 3 trial data.
Bimekizumab demonstrates sustained benefits in PsA, ankylosing spondylitis
Follow-up results from the BE ACTIVE and BE AGILE phase 2b trials show that the efficacy and safety profiles of bimekizumab are maintained for up to 3 years in patients with psoriatic arthritis or ankylosing spondylitis.
Diabetes burden expanding in the Americas
Diabetes burden is large, heterogenous, and has increased across all six regions of the Americas since 1990, mostly as a result of type 2 diabetes, show data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019.
ICIs associated with increased MACE risk
People with cancer receiving immune checkpoint inhibitors have a significantly higher risk for major adverse cardiovascular events than their unexposed counterparts or the general population, indicate real-world findings.
Genetic testing has variable diagnostic yield in congenital diaphragmatic hernia
Genetic testing can identify an underlying cause in more than half of complex/syndromic infants with congenital diaphragmatic hernia, but factors underlying isolated cases remain elusive, say researchers.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Cancer screening declined globally during COVID-19 pandemic
A systematic review and meta-analysis has identified global decreases in breast, cervical, and colorectal cancer screening during the early phase of the COVID-19 pandemic.
Two early childhood autoantibody screenings predict most type 1 diabetes cases
Testing high-risk children for islet autoantibodies twice, at the ages of 2 and 6 years, predicts the majority of clinical cases of type 1 diabetes diagnosed by the age of 15, a study suggests.
TNF inhibitors linked to higher psoriasis risk than other RA treatments
Treatment with tumor necrosis factor inhibitors (TNFi) is associated with a twofold increased risk for new-onset psoriasis compared with nonbiologic agents, suggest findings from a Danish cohort study.