Trastuzumab deruxtecan-related ILD/pneumonitis characterized
A pooled analysis of nine early-phase trials of trastuzumab deruxtecan monotherapy has identified an incidence of drug-related interstitial lung disease/pneumonitis of 15.4%.
Pros and cons with lower vs higher threshold for gestational diabetes diagnosis
Using the lower IADPSG glycemic criteria rather than the HAPO criteria diagnoses more women with gestational diabetes but does not result in fewer babies being born large for gestational age, shows a randomized trial.
‘Diverse’ comorbidities characterize people with type 2 diabetes
Only two of the five most common comorbidities identified in a UK population with type 2 diabetes are traditionally associated with the condition, say researchers.
NADIM II: Adding nivolumab to neoadjuvant chemo improves stage III NSCLC survival
The addition of nivolumab to neoadjuvant chemotherapy significantly improves the survival of individuals with resectable stage IIIA–B non-small-cell lung cancer, suggest data from NADIM II.
Lifestyle intervention strategy beneficial for older adults with diabetes
Lifestyle intervention proves “highly successful” in adults with diabetes aged 65 to 85 years, improving both metabolic and functional health, report researchers.
Long COVID risk small in children
Researchers find a high burden of non-specific persistent symptoms in children aged 14 years or younger, with SARS-CoV-2 infection adding to this only slightly.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Gout flares linked to temporary increase in cardiovascular risk
Gout flares are associated with an increased risk for cardiovascular events in the following 120 days, study findings suggest.
Adolescent, young adult patients might benefit from intensive rhabdomyosarcoma treatment
Adolescent and young adults with rhabdomyosarcoma have more aggressive disease than their paediatric counterparts and might benefit from intensive treatment strategies, suggests an analysis of two European paediatric Soft tissue sarcoma Study Group trials.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
TNF inhibitor use during pregnancy linked to higher infant birthweight
Tumor necrosis factor inhibitor use by pregnant women with well-controlled rheumatoid arthritis is associated with a reduced risk for having a child that is born small for gestational age, study findings indicate.
No justification for bespoke antihypertensive intervention in type 2 diabetes
Author: Eleanor McDermid medwireNews: The absolute benefit of blood pressure reduction on cardiovascular risk does not differ according to whether or not people have type 2 diabetes, shows an individual participant data meta-analysis. Kazem Rahimi (University of Oxford, UK) and colleagues from the Blood Pressure Lowering Treatment Trialists’ Collaboration analyzed 358,533 participants of 51 randomized […]