Early surgery improves survival for children with drug-resistant epilepsy
Study findings highlight the importance of a multidisciplinary comprehensive approach to drug-resistant epilepsy in children, with the consideration of both medical and surgical treatment options.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Pathogenic variants have additive effect on ALS survival
Genetic variants that modify survival in amyotrophic lateral sclerosis (ALS) can act on their own or in unison, having an additive effect and significantly worsening a patient’s outcome, researchers report in the journal Neurology.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Glucocorticoid withdrawal prevalent and persistent after hypercortisolism surgery
Myalgias and arthralgias are prominent symptoms associated with glucocorticoid withdrawal syndrome following surgical remission of endogenous hypercortisolism, report Irina Bancos, from the Mayo Clinic in Rochester, Minnesota, USA, and colleagues.
Urinary DKK3 signals declining kidney function and treatment response in children
Increased urinary Dickkopf-related protein 3 levels could indicate declining kidney function in children with chronic kidney disease and be a marker of treatment response, report researchers in The Lancet Child and Adolescent Health.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Autoantibodies may identify Sjögren’s syndrome in Ro-negative patients
The use of autoantibody biomarkers could be a feasible way of identifying Sjögren’s syndrome in patients lacking the anti-Ro antibody without the need for a salivary gland lip biopsy, suggests a proof-of-concept study.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Intracerebral polio–rhinovirus immunotherapy feasible for paediatric malignant glioma
Intracerebral recombinant polio–rhinovirus immunotherapy is feasible in children and young people with heavily pretreated, high-grade malignant glioma, suggest phase 1b trial findings published in The Lancet Child & Adolescent Health.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Serious infection risk not increased by rituximab and belimumab in SLE
Neither rituximab nor belimumab significantly increase the risk for serious infection in patients with systemic lupus erythematosus compared with the standard of care, researchers report.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Bone fragility management justified for postmenopausal women with MACS
Postmenopausal women with adrenal incidentalomas associated with mild autonomous cortisol secretion have a “considerable fracture burden”, report Guido Di Dalmazi and colleagues.
Multimodal genome-wide analysis pinpoints hard-to-diagnose developmental disorders
The Deciphering Developmental Disorders study has provided genetic diagnoses for thousands of children with severe developmental disorders in the UK and Ireland, report the investigators in The New England Journal of Medicine.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
α-synuclein seed amplification potential for early Parkinson’s disease diagnosis
An assay for identifying the build-up of the misfolded α-synuclein protein in cerebrospinal fluid could enhance the detection of Parkinson’s disease in the early stages before the onset of motor symptoms, suggests research.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
