CAR T cells show promise for treatment of autoimmune diseases
CD19 chimeric antigen receptor T-cell therapy appears to be “feasible, safe, and efficacious” for the treatment of three autoimmune diseases, researchers report.
Mycophenolate mofetil withdrawal feasible in SLE patients with stable disease
Patients with systemic lupus erythematosus may be able to stop taking mycophenolate mofetil once their condition becomes stable without significantly increasing their risk for flare compared with continuing treatment, suggests an open-label, randomized controlled trial.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Add-on telitacicept improves clinical response in patients with active SLE
Telitacicept used in addition to standard therapy shows promising efficacy in Chinese patients with active systemic lupus erythematosus, suggests a phase 2b trial published in the Annals of the Rheumatic Diseases.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Respiratory infection risk heightened in primary Sjögren’s syndrome and ILD
Patients with primary Sjögren’s syndrome and interstitial lung disease are at increased risk of respiratory infections, particularly bacterial infections, suggests a study published in Clinical Rheumatology.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Remibrutinib shows promise for Sjögren’s syndrome treatment
The Bruton’s tyrosine kinase inhibitor remibrutinib reduces disease activity in patients with Sjögren’s syndrome, show results from the phase 2 LOUiSSE trial.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Diffusing capacity of lung for carbon monoxide predicts SLE disease severity
The diffusing capacity of the lungs for carbon monoxide could be a surrogate marker for overall disease severity in patients with systemic lupus erythematosus, suggest researchers in Rheumatology.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Complete remission best for tapering SLE treatment
To prevent systemic lupus erythematosus flare, tapering of corticosteroid or immunosuppressive therapy is best done when patients are in complete remission and have maintained stable disease for at least 6 months, say researchers.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Add-on tofacitinib shows treatment promise in SSc-ILD
The addition of tofacitinib to conventional disease-modifying antirheumatic drugs could help alleviate sclerosis in patients with systemic sclerosis-associated interstitial lung disease, suggests research.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Autoantibodies may identify Sjögren’s syndrome in Ro-negative patients
The use of autoantibody biomarkers could be a feasible way of identifying Sjögren’s syndrome in patients lacking the anti-Ro antibody without the need for a salivary gland lip biopsy, suggests a proof-of-concept study.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Serious infection risk not increased by rituximab and belimumab in SLE
Neither rituximab nor belimumab significantly increase the risk for serious infection in patients with systemic lupus erythematosus compared with the standard of care, researchers report.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
