Cost drives one in six US adults to ration insulin
Findings from a nationally representative US survey show that a substantial minority of people with diabetes ration their use of insulin because of issues with affordability.
First-line SGLT2 inhibitors, GLP-1 receptor agonists ‘not cost effective’
Researchers calculate that the price of SGLT2 inhibitors and GLP-1 receptor agonists would need to fall “by at least 70%” to make them cost effective first-line treatments in the USA.
High IL-6, CRP may predict increased frailty after breast cancer chemotherapy
Clinically fit older women with early breast cancer are more likely to experience chemotherapy-induced decline in frailty if they have high pretreatment levels of IL-6 and CRP, research shows.
Study identifies sex differences in RA remission rates
Men with rheumatoid arthritis initiating treatment with biologic or targeted synthetic DMARDs may be more likely to achieve remission than women, suggests research reported at The Lancet Summit: Sex and gender in rheumatology.
Incidental sinoatrial node irradiation may increase AF risk in lung cancer
Incidental irradiation of the sinoatrial node during lung cancer chemoradiotherapy may be associated with an increased risk for atrial fibrillation and death, research suggests.
SEMAPHORE: Tocilizumab reduces disease activity in steroid-dependent polymyalgia rheumatica
The IL-6 receptor inhibitor tocilizumab may significantly reduce disease activity and the amount of prednisone needed in people with glucocorticoid-dependent active polymyalgia rheumatica, suggest results from a phase 3 trial published in JAMA.
Extended anastrozole benefits dependent on tumor characteristics
Extending adjuvant aromatase inhibition to beyond 5 years of sequential therapy should not be recommended to all postmenopausal women with hormone receptor-positive early breast cancer, but some subgroups may benefit, research suggests.
Online yoga program shows limited benefits for knee osteoarthritis
People with knee osteoarthritis may experience modest improvements in physical function while following a 12-week self-guided online yoga program, but the benefits are not sustained when the exercise is stopped, researchers report.
Analysis points to FOLFIRINOX chemotherapy benefits for metastatic pancreatic cancer
FOLFIRINOX chemotherapy may offer better survival than gemcitabine plus nab-paclitaxel for patients with metastatic pancreatic ductal adenocarcinoma, suggests a comparative effectiveness study published in JAMA Network Open.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.
Monoclonal antibodies disappoint in early Parkinson’s disease
Two monoclonal antibodies targeting aggregated α-synuclein have failed to improve clinical or imaging measures of Parkinson’s disease progression in the early-stage setting.
This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.