‘The Great Debate’: JAK inhibitors vs biologics following methotrexate failure in RA
Author: Claire Barnard medwireNews: “The Great Debate” of the ACR Convergence 2020 virtual meeting addressed the question of whether Janus kinase (JAK) inhibitors should be given before biologics following an inadequate response to methotrexate in patients with rheumatoid arthritis (RA). Introducing the topic, Elizabeth Wahl, from the University of Washington in Seattle, USA, said that […]
Managing psoriatic arthritis in resource-limited settings
Author: Claire Barnard Challenges, guidelines, and research priorities Psoriatic arthritis (PsA), a heterogeneous disease involving multiple domains, can be challenging to manage, particularly in resource-limited settings. With the majority of published research studies in PsA coming from resource-rich countries, guidelines from organizations including the European League Against Rheumatism (EULAR), the American College of Rheumatology (ACR), […]
In pursuit of new lupus therapies: The importance of trial endpoints
Author: Claire Barnard The two phase 3 trials of anifrolumab for the treatment of systemic lupus erythematosus (SLE) reported different primary results, with TULIP-1 finding no significant difference in SRI-4 response rates among patients treated with anifrolumab versus placebo, and TULIP-2 demonstrating significantly higher BICLA response rates with the type I interferon receptor-targeted monoclonal antibody. Why did these two trials report apparently contradictory […]
A closer look at the ACR guidance on COVID-19 and rheumatology care
Speaker: Ted Mikuls In April 2020, the American College of Rheumatology issued guidance for the management of people with rheumatic diseases during the COVID-19 pandemic. We spoke to lead author Ted Mikuls, from the University of Nebraska Medical Center in the USA, to find out more about what rheumatologists should do to best care for their patients […]
The COVID-19 Global Rheumatology Alliance registry: What you need to know
Philip Robinson, chair of the steering committee for the COVID-19 Global Rheumatology Alliance, tells us about the initiative that will enable rheumatologists to document their patient experiences of COVID-19 and contribute to a shared learning resource (17:28). The coronavirus pandemic is affecting all healthcare professionals across the globe. Medicine Matters’ focus, in this difficult time, […]
At a glance: Common scores used in rheumatology
Author: Claire Barnard A number of different scores, many of them composite outcomes, are used in daily rheumatology practice and in clinical trials to assess the efficacy of new treatments. This article provides a quick-reference guide to the criteria that are commonly used, together with an explanation of the component parts making up the individual […]
At a glance: The ORAL trials of tofacitinib for the treatment of RA
Our quick-reference guide to the seven ORAL trials of tofacitinib for the treatment of rheumatoid arthritis that have been completed to date.
