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26-01-2022 | Rheumatology | News | Article

approvalsWatch

FDA approves risankizumab for psoriatic arthritis

Author: Claire Barnard

medwireNews: The indication for risankizumab has been expanded to include psoriatic arthritis (PsA) in the USA.

Previously approved for plaque psoriasis, the interleukin-23 inhibitor may now be given to adult patients with active PsA at a dose of 150 mg every 12 weeks, following loading doses at weeks 0 and 4, and is administered by subcutaneous injection. Risankizumab may be used alone or in combination with nonbiologic DMARDs.

This FDA approval is based on findings from the placebo-controlled KEEPsAKE 1 and 2 trials, which showed that risankizumab significantly improved a range of PsA outcomes. KEEPsAKE 1 included patients with an inadequate response to conventional DMARDs but no prior biologic exposure, whereas KEEPsAKE 2 also included those with prior biologic exposure.

Click through to watch Laura Coates discuss how risankizumab may fit in the treatment landscape for psoriatic arthritis

Commenting on the announcement, Saakshi Khattri (Mount Sinai Hospital, New York, USA) says that the approval of the risankizumab “is great news because it adds another biologic treatment to our arsenal to better care for our patients with skin and joint symptoms.”

medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2022 Springer Healthcare Ltd, part of the Springer Nature Group

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