Evaluation of pulmonary arterial compliance after initiation or escalation of therapy for pulmonary arterial hypertension more accurately predicts prognosis than conventional right heart hemodynamic parameters, Italian study findings indicate.
A post-hoc subgroup analysis of the AMBITION trial suggests that the benefits of ambrisentan and tadalafil combination therapy extend to patients with connective tissue disease-associated pulmonary arterial hypertension.
Research published in the Journal of the American College of Cardiology suggests that there could be a pathophysiological overlap between combined post-capillary and pre-capillary pulmonary hypertension and pulmonary arterial hypertension.
N-terminal pro-B-type natriuretic peptide may be more accurate than B-type natriuretic peptide for detecting and monitoring pulmonary arterial hypertension in patients with systemic sclerosis, study findings suggest.
Pulmonary arterial hypertension-related hospitalization rates have fallen significantly in the USA since 2001, but the cost of each hospitalization has risen substantially and is increasingly paid for by Medicare, study findings indicate.
A single bout of exercise causes immediate changes in circulating T lymphocyte levels and improvements in the altered cytokine profile of patients with idiopathic pulmonary arterial hypertension, without aggravating the inflammatory state, researchers report.
Reduced nitric oxide synthesis appears to play a role in the pathogenesis of idiopathic pulmonary arterial hypertension and measuring plasma levels of the resulting nitrate and nitrite metabolites could help predict outcome, research suggests.
Including gas exchange measurements during the 6-minute walk distance test may give a better indication of disease severity in patients with pulmonary arterial hypertension than the walk test alone, researchers report.
Performing right heart catheterisation to classify pulmonary arterial hypertension ahead of initiating medication, in line with consensus guidelines, does not appear to be carried out as often as it should, findings from a US-based population suggest.