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Pharmacology

Pharmacology

22-04-2013 | Gynaecology | Article

Tamoxifen breast changes predict survival

Women with breast cancer who experience a tamoxifen-related decrease in mammographic density have significantly better survival than patients whose breast density is unaffected by the agent, suggest study findings.

21-04-2013 | Nephrology | Article

Bolus iron fights hemodialysis patient anemia

Research suggests that bolus intravenous iron could be the optimal treatment for anemia in patients undergoing hemodialysis, subject to further investigation.

18-04-2013 | Metabolism | Article

mTOT modulator shows proof-of-concept in diabetes

A proof-of-concept study indicates that treatment with a mitochondrial target of thiazolidinediones modulator effectively lowers glucose levels in patients with Type 2 diabetes.

15-04-2013 | Oncology | Article

Dose-intense chemotherapy not superior for B-cell lymphoma

Compressing R-CHOP treatment cycles does not improve the outcome of elderly patients with diffuse large B-cell lymphoma, suggests research published in The Lancet Oncology.

14-04-2013 | General practice | Article

Bisphosphonate therapy may aid osteoarthritis patients

Research adds weight to reports that patients with knee osteoarthritis may experience benefits in pain or progression relief from bisphosphonate treatment.

11-04-2013 | Oncology | Article

Irsogladine helps limit chemotherapy-induced oral mucositis

Irsogladine maleate is a promising drug for the management of oral mucositis in patients undergoing 5-fluorouracil-based chemotherapy, results of a randomized placebo-controlled trial indicate.

11-04-2013 | Cardiology | Article

Guideline-directed HF therapy ‘saves money and lives’

Medical treatment of heart failure in line with current clinical guidelines is highly cost-effective and may even be cost-saving, study findings indicate.

10-04-2013 | Gastroenterology | Article

Pediatric GERD label should be used with caution

Parents are more interested in requesting acid-reducing medications for their children when symptoms of crying and excessive regurgitation are labelled as gastroesophageal reflux disease, researchers say.

08-04-2013 | Immunology | Article

Etanercept reaps workplace benefits

The cost of treatment with the tumor necrosis factor inhibitor etanercept is offset by increased ability to work, suggests a study of US patients with moderate-to-severe rheumatoid arthritis.

04-04-2013 | Cardiometabolic | Article

Statins ‘commonly stopped, restarted’

The factors that influence compliance with statin therapy are complex, with high rates of statin discontinuation yet also high long-term tolerance when rechallenged, shows research.

04-04-2013 | Metabolism | Article

Calcium channel blockers best for managing hypertension in diabetes

Calcium channel blockers stabilize morning blood pressure variability to a greater extent than other antihypertensive medications in patients with hypertension and Type 2 diabetes, suggest study findings.

02-04-2013 | Cardiology | Article

CLUE to emergency antihypertensive approach for end-organ damage

Patients admitted to the emergency department with hypertension and suspected end-organ damage reach target systolic blood pressure faster with a nicardipine infusion than a labetalol bolus, research suggests.

02-04-2013 | General practice | Article

Marital status affects place of cancer death

Having a hematologic cancer or being single, widowed, or divorced, reduces cancer patients’ chances for dying at home or in a hospice, study findings show.

27-03-2013 | Oncology | Article

Induction chemotherapy cuts metastasis risk in resectable HNSCC

Induction chemotherapy offers significant benefits in the management of resectable squamous cell carcinoma of the head and neck, Chinese researchers believe.

26-03-2013 | Cardiology | Article

Chelation therapy on hold for cardiac patients

The findings of the controversial Trial to Assess Chelation Therapy have been published in JAMA.

26-03-2013 | Surgery | Article

Anal intraepithelial neoplasia best treated by electrocauterization

Electrocauterization is better than topical treatments for treating anal intraepithelial neoplasia in HIV-positive men who have sex with men, Dutch study findings suggest.

25-03-2013 | Metabolism | Article

Meta-analysis shows reduced dementia risk with statin use

A meta-analysis of eight prospective cohort studies looking at the effect of treatment with statins has shown a significant reduction in dementia risk.

25-03-2013 | Gynaecology | Article

Vitamin D pregnancy advice ‘overstated’

UK researchers have raised questions about recommendations for vitamin D supplementation after finding that maternal vitamin D levels during pregnancy are not linked to the child’s future bone health.

25-03-2013 | Gynaecology | Article

Joint pain benefits suggested for hormone therapy

Postmenopausal women with joint pain may benefit from taking estrogen-only hormone therapy, research suggests.

24-03-2013 | Pathology | Article

Childhood chemotherapy may raise renal cancer risk

Adults who survived childhood cancer may have an increased risk for renal carcinoma, suggests research published in the Journal of the National Cancer Institute.