Metabolic syndrome common in Indian bipolar disorder patients
MedWire News: Results from an Indian study suggest that the metabolic syndrome is highly prevalent among patients with bipolar disorder, with abdominal obesity being the most common component.
A large number of studies have shown that the metabolic syndrome is common among patients with schizophrenia, but less is known about prevalence of the syndrome among patients with bipolar disorder, particularly among Indian patients, observe Sandeep Grover and colleagues from the Postgraduate Institute of Medical Education and Research in Chandigarh.
To address this, the researchers studied 200 patients, aged at least 18 years (mean age 39 years), with the mood disorder who were receiving treatment at a psychiatry clinic in North India.
The mean duration of illness was 130.6 months, most of the patients were receiving a conventional mood stabilizer, and more than half were also taking antipsychotic medications.
Prevalence of the metabolic syndrome, and its individual components, was assessed using both International Diabetes Federation (IDF) criteria and modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) criteria.
The researchers found that 82 (41.0%) patients fulfilled modified NCEP ATP-III criteria for the metabolic syndrome and 80 (40.0%) fulfilled IDF criteria, with significant concordance between the two assessment methods.
The most prevalent component of the metabolic syndrome among the patients was abdominal obesity (>90 cm for men and >80 cm for women), at 70.5%, followed by increased blood pressure (≥130/≥85mmHg), at 44.5%, and increased triglycerides levels (≥150 mg), at 42.0%.
Patients with metabolic syndrome had a significantly higher mean body mass index than those without, at 28.18 versus 24.33 kg/m2, and were more likely to be over 35 years of age, at 74.4% versus 51.7%. Indeed, binary logistic regression analysis revealed that both of these factors significantly predicted the metabolic syndrome among the patients.
Grover and team conclude that the metabolic syndrome is common in patients with bipolar disorder and "is best predicted… by higher age and higher body mass index."
They add: "These findings suggest that monitoring body mass index along with waist circumference can be useful in monitoring the development of possible metabolic syndrome."
The research is published in the journal Progress in Neuro-Psychopharmacology and Biological Psychiatry.
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By Mark Cowen