Physical activity beneficial for cardiorespiratory fitness in lymphoma survivors
medwireNews: High levels of physical activity could counteract the negative effects on cardiorespiratory fitness of intensive treatment in long-term lymphoma survivors who have undergone high-dose chemotherapy with autologous stem cell transplantation, research suggests.
The researchers used peak oxygen uptake (VO2peak) as determined by cardiopulmonary exercise testing to ascertain cardiorespiratory fitness. They also calculated the percent-predicted VO2peak, by dividing the measured VO2peak values by those derived from age- and gender-dependent equations from a healthy sedentary population.
Among 194 individuals without heart failure who were treated for Hodgkin’s or non-Hodgkin’s lymphoma between 1987 and 2008 at two Norwegian hospitals, 22% had impaired VO2peak, defined as a percent-predicted value of less than 80%.
The percent-predicted VO2peak was an average 4.5% and 7.7% lower for female and male patients, respectively, relative to the age- and gender-predicted values from the reference population.
And when patients were stratified by level of physical activity, those who reported low activity had a significantly lower mean percent-predicted VO2peak than the reference population, at 87.5% for females and 85.8% for males.
By contrast, the VO2peak values of lymphoma survivors in the high activity group were comparable to those of the reference population, at 105.6% and 100.9% for women and men, respectively.
In multivariate analysis, high levels of physical activity were associated with improved VO2peak, while current smoking and impaired diffusion capacity significantly predicted a decrease in VO2peak.
Jo Stenehjem, from Oslo University Hospital in Norway, and co-investigators, report that during an average 10.2 years of follow-up, just under half (47%) of the included lymphoma survivors met the WHO recommendations on physical activity, while 17% were current smokers.
As both factors are modifiable lifestyle factors, the authors suggest oncologists pay “increased attention towards physical activity counseling/interventions and smoking cessation advice in this patient group.”
And they conclude in the British Journal of Cancer that “[i]ndividuals with impaired diffusion capacity may benefit from subsequent monitoring to detect pulmonary vascular diseases.”
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