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Lung cancer

Lung cancer

17-05-2019 | Oncology | News | Article

CTCs prognostic in limited-stage SCLC

The circulating tumor cell count can identify patients with limited-stage small-cell lung cancer who are likely to have poor survival outcomes despite treatment, report researchers who have identified 15 cells per 7.5 mL as the optimal cutoff.

16-05-2019 | Oncology | News | Article

Immunotherapy response differs by EFGR mutation subtype

The response to treatment with immune checkpoint inhibitors varies according to EGFR mutant subtype in patients with non-small-cell lung cancer, US researchers report.

14-05-2019 | Oncology | Highlight | Article

Whole-body MRI staging quicker and cheaper than standard pathways in NSCLC

The Streamline L trial has found that in patients with newly diagnosed non-small-cell lung cancer, a staging pathway using whole-body magnetic resonance imaging has similar accuracy but a shorter time to complete staging and lower mean per-patient costs versus standard pathways.

13-05-2019 | Oncology | News | Article

Local consolidative therapy improves oligometastatic NSCLC survival

Patients with stage IV non-small-cell lung cancer and no more than three metastases derive an overall survival benefit from aggressive local consolidative therapy, suggest trial results.

07-05-2019 | Oncology | News | Article

Immunotherapy-related AEs reviewed, underlying mechanism postulated

Researchers have comprehensively analyzed the incidence of adverse events in trials of PD-1 and PD-L1 inhibitors, while another team has provided insight into the potential pathophysiologic process underlying these effects.

03-05-2019 | Oncology | News | Article

Mesothelioma survival doubles with radical hemi-thoracic radiotherapy regimen

Switching palliative radiation for high-dose radical hemi-thoracic radiotherapy significantly increases 2-year overall survival among patients with a new diagnosis of malignant pleural mesothelioma, delegates were told at the ESTRO 38 meeting in Milan, Italy.

02-05-2019 | Oncology | News | Article

Biologic, genetic markers predict radiation toxicity in oncology patients

A combination of biologic and genetic markers may be useful to predict which patients will experience toxicity following radiotherapy, suggest data presented at the ESTRO 38 conference in Milan, Italy.

30-04-2019 | Oncology | News | Article

Clinicogenomic database yields clinically relevant insights in NSCLC

US researchers have replicated previously described associations between patient and tumor characteristics and clinical outcomes using routinely collected clinical and genomic data for patients with non-small-cell lung cancer.

29-04-2019 | Lung cancer | News | Article

ALESIA backs first-line alectinib in Asian NSCLC patients

Previously untreated Asian patients with advanced ALK translocation-positive non-small-cell lung cancer derive a significant progression-free survival benefit from alectinib over crizotinib, indicate phase III trial results.

26-04-2019 | Oncology | News | Article

Crizotinib offers long-term benefits in ROS1-rearranged advanced NSCLC

Crizotinib provides durable clinical benefit to patients with ROS1-rearranged advanced non-small-cell lung cancer, show updated PROFILE 1001 data.

24-04-2019 | Oncology | News | Article

Bevacizumab–erlotinib improves PFS in advanced EGFR mutation-positive NSCLC

Combining erlotinib with bevacizumab is associated with a significant prolongation of progression-free survival in chemotherapy-naïve patients with advanced nonsquamous non-small-cell lung cancer harboring an activating EGFR mutation, indicates a phase III trial.

23-04-2019 | Oncology | News | Article

SABR may improve survival in oligometastatic cancer

The phase II SABR-COMET study has indicated that stereotactic ablative radiotherapy prolongs overall and progression-free survival versus palliative treatment in patients with up to five oligometastases.

18-04-2019 | Oncology | News | Article

ABCP benefits shown in key NSCLC subgroups

Patients with nonsquamous non-small-cell lung cancer who have sensitizing EGFR mutations or liver metastases may benefit from the addition of atezolizumab to bevacizumab and chemotherapy, IMpower150 trial data show.

17-04-2019 | Oncology | News | Article

Conflicting data reported on immunotherapy benefit for older NSCLC patients

The overall survival benefit of immunotherapy in elderly patients with advanced non-small-cell lung cancer is unclear according to two studies with contradictory results presented at the European Lung Cancer Congress 2019 in Geneva, Switzerland.

16-04-2019 | Oncology | News | Article

CheckMate 451: Maintenance immunotherapy fails to improve SCLC survival

Maintenance treatment with nivolumab, either given alone or alongside ipilimumab, does not prolong the overall survival of patients with extensive-stage small-cell lung cancer, the CheckMate 451 investigators have found.

12-04-2019 | Oncology | News | Article

ALK resistance mutations predict lorlatinib efficacy in NSCLC patients progressing on ALK–TKIs

Lorlatinib is more efficacious against non-small-cell lung cancer with versus without ALK resistance mutations in patients with disease progression after at least one second-generation ALK–tyrosine kinase inhibitor, suggests research.

12-04-2019 | Oncology | News | Article

KEYNOTE-042 leads to first-line pembrolizumab approval for stage III NSCLC

Read more on this FDA announcement here

12-04-2019 | Oncology | News | Article

Lung cancer screening benefits increase over time

The Multicentric Italian Lung Detection study findings indicate that extending lung cancer screening beyond 5 years boosts the survival benefits associated with early disease detection.

10-04-2019 | Oncology | News | Article

Clinical value of genotyping cfDNA demonstrated in advanced NSCLC setting

The NILE study has shown the noninferiority of cell-free DNA analysis, so-called liquid biopsy, to the standard of care for identifying targetable biomarkers in individuals with treatment-naïve metastatic non-small-cell lung cancer.

09-04-2019 | Oncology | News | Article

Durvalumab maintenance for unresectable NSCLC approved for UK patients

Read more on this decision here

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