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15-11-2011 | Diabetes | Article

Serum TG strong CHD predictor in Japanese diabetes patients

Abstract

Free abstract

MedWire News: Serum triglyceride (TG) level is strongly associated with coronary heart disease (CHD) risk in Japanese patients with Type 2 diabetes, having similar predictive value to low-density lipoprotein cholesterol (LDL cholesterol), suggest study findings.

The results imply that physicians should pay more attention to serum TG levels in these patients, report the authors in Journal of Clinical Endocrinology and Metabolism.

Led by Hirohito Sone (University of Tsukuba Institute of Clinical Medicine, Ibaraki), the researchers conducted a prospective study of 940 men and 831 women with Type 2 diabetes (mean age 58.2 years) without a history of CV complications.

The team followed-up the patients over a mean period of 7.86 years for incidence of CHD events (angina and myocardial infarction) and stroke events (cerebral infarction, intracranial hemorrhage, transient ischemic attack, or stroke of undetermined type).

By the end of the study, the crude incidence of CHD was 9.59 per 1000 patient-years, while that for stroke was 7.45 per 1000 patient-years.

Multivariate analysis revealed that serum levels of LDL cholesterol and TG were the strongest of seven independent predictors for CHD.

Serum LDL cholesterol and TG were both associated with an approximate 1.5-fold increase in CHD risk for each standard deviation increment.

Similarly, the hazard ratios for CHD associated with each 1 mmol/L increment were 1.64 and 1.63 for LDL cholesterol and TG, respectively.

The only significant predictor for stroke other than age was systolic blood pressure, with each 10-mmHg increment associated with a 1.18-fold increased risk.

The authors say their relatively large-scale, long-term prospective study supports previous research indicating that TG is one of the leading predictors for CHD, comparable to LDL cholesterol, in East Asian subjects with Type 2 diabetes.

"Although serum TG seems to have significant influence on CV complications in diabetes patients in East Asia, it has not previously been confirmed by large-scale prospective studies," they say.

"In this sense, although lowering levels of LDL cholesterol is given priority over that of TG in most current guidelines for diabetes, more attention should be given in East Asian individuals with diabetes," concludes the team.

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By Sally Robertson