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23-06-2010 | Diabetes | Article

Oxidative stress gene variants implicated in diabetic MI

Abstract

Free abstract

MedWire News: The accumulation of genetic polymorphisms relating to oxidative stress could be associated with the prevalence of myocardial infarction (MI) in patients with Type 2 diabetes, Japanese study findings suggest.

The researchers say that combining information about these variants could therefore be of use in assessing the risk for MI.

Oxidative stress, which is provoked in patients with diabetes, may play a critical role in the pathogenesis of MI, note Naoto Katakami (Osaka University Graduate School of Medicine, Japan) and colleagues.

They assessed the potential contribution of five relatively common genetic variants relating to oxidative stress in 3819 Japanese patients with Type 2 diabetes.

The polymorphisms assessed included glutamate-cysteine ligase modifier subunit (GCLM) C-588T, manganese superoxide dismutase (SOD2) Val16Ala, endothelial nitric oxide synthase (NOS3) G894T, NAD(P)H oxidase p22phox (CYBA) C242T, and myeloperoxidase (MPO) G-463A.

The researchers report no statistically significant associations between each polymorphism individually and the prevalence of MI.

However, when the combined effect of these polymorphisms was assessed, there was a statistically significant, graded relationship between the number of pro-oxidant alleles and the prevalence of MI.

Multiple logistic regression analysis revealed that the number of pro-oxidant alleles was a risk factor for MI independently of conventional risk factors, with an odds ratio of 1.16 for each increase in the number.

Reporting in the journal Atherosclerosis, the team says: “These results suggest that the accumulation of pro-oxidant alleles is associated with the prevalence of MI independently of conventional risk factors and that that it is important to examine these polymorphisms together, when we estimate whether each subject is predisposed to MI.”

MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a part of Springer Science+Business Media. © Current Medicine Group Ltd; 2009

MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Anita Wilkinson