Bone markers ‘normal’ in postmenopausal women with Type 2 diabetes
MedWire News: Bone turnover markers, bone mineral density (BMD), and bone loss rates are within normal ranges among postmenopausal women with Type 2 diabetes, say Polish researchers, who found that total adiponectin was inversely linked to bone measures.
Tomasz Miazgowski and colleagues, from Pomeranian Medical University in Szczecin, studied 57 postmenopausal women, aged 50-78 years, who were newly diagnosed with Type 2 diabetes. They measured serum total adiponectin, bone alkaline phosphatase levels, glycated hemoglobin (HbA1c), urinary deoxypyridinoline excretion, and total body, lumbar spine, and total hip BMD.
The participants had high rates of overweight or obesity, hypertension, abdominal obesity, increased low-density lipoprotein levels, reduced high-density lipoprotein, and hypertriglyceridemia, at 88%, 86%, 86%, 72%, 32%, and 47%, respectively.
Writing in the journal Diabetic Medicine, the team reports that the women had normal bone alkaline phosphatase and deoxypyridinoline levels, as well as normal BMD of the total hip and lumbar spine, as assessed by t- and z-scores.
Significant decreases in body weight, body mass index, waist circumference, and HbA1c were recorded at 1 year. Furthermore, BMD of the total body, lumbar spine, and total hip reduced by 0.4%, 0.2%, and 1.0% per year, respectively. Improvements in diabetes control had no effect on bone turnover marker levels, which did not alter significantly.
There were significant inverse correlations between serum adiponectin levels and BMD of the total body, lumbar spine, and total hip. During the first 6 months of treatment, there was a transient, significant increase in adiponectin levels, which was followed by a steady decline back to baseline levels in the next 6 months.
The team writes: "Our results suggest that mechanisms independent of bone mineral density are responsible for the increased fracture risk observed in some osteoporosis studies in post-menopausal women with Type 2 diabetes."
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By Liam Davenport