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13-07-2010 | Cardiometabolic | Article

Three metabolic syndrome components predict its development


Free abstract

MedWire News: Iranian researchers may have identified the three most important components of the metabolic syndrome that can predict development of the condition.

Waist circumference and plasma levels of high-density lipoprotein (HDL) cholesterol and triglycerides predicted the development of the metabolic syndrome better than blood pressure or glucose levels, they report.

And a model that included waist circumference, HDL cholesterol, and triglycerides had similar predictive power to when all five metabolic syndrome components were included.

The findings come from a study of 2279 individuals, aged 22 to 87 years, who initially did not have the metabolic syndrome and were part of the cross-sectional phase of the Tehran Lipid and Glucose Study.

After a mean of 6.5 years, 462 participants were diagnosed with the metabolic syndrome on the basis of the modified National Cholesterol Education Program Adult Treatment Panel (NCEP-ATP)III criteria, and 602 based on the International Diabetes Federation (IDF) criteria.

The adjusted odds ratio (OR) for developing the metabolic syndrome according to the NCEP-ATP III criteria was highest for central obesity in men and high triglycerides (>150 mg/100 ml) in women, at 2.8 in each case.

When the IDF criteria were used the OR was highest for high triglycerides in both men and women, at a corresponding 2.8 and 2.9, report F Azizi and co-workers at Shahid Beheshti University of Medical Science in Tehran.

Reporting in the European Journal of Clinical Nutrition, the researchers conclude: "High-risk subjects should undergo periodic screening for the timely prediction of the development of [the metabolic syndrome], including measurement of [waist circumference], triglycerides, and plasma HDL."

MedWire ( is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Anita Wilkinson