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31-10-2011 | Cardiometabolic | Article

Lack of association between resistin levels and the metabolic syndrome


Free abstract

MedWire News: Results of a Spanish study suggest there are no significant associations between serum resistin levels and the number of metabolic syndrome determinants or the diagnosis of the metabolic syndrome in obese women.

The researchers explain that expression of resistin, an adipocytokine, has been shown to be induced by adipocyte differentiation. Some adipocytokines have been implicated in the pathogenesis of the metabolic syndrome, they add, but published data are controversial.

Daniel de Luis (University of Valladolid) and colleagues therefore investigated the association between serum resistin levels and the metabolic syndrome in 551 obese (body mass index [BMI] ≥30 kg/m2) women. Presence of the metabolic syndrome was determined according to the National Cholesterol Education Program Adult Treatment Panel (NCEP ATP)-III criteria.

In total, 255 (46.3%) of the female participants had the metabolic syndrome.

The team found that levels of C-reactive protein (CRP), weight, fat mass, and waist circumference were significantly higher among patients in the highest tertile of resistin (>4.7 ng/mL) than those in the lowest (<3.2 ng/mL) or middle (3.2-4.7 ng/mL) tertiles. Furthermore, correlation analysis revealed significant associations between serum resistin levels and the independent variables weight, BMI, waist circumference, fat mass, and CRP.

However, in the multivariate analysis only fat mass remained an independent predictor of resistin levels. Specifically, each kilogram increase in fat mass was associated with a 0.020 ng/mL increase in resistin levels.

"This could demonstrate an indirect relation of both molecules [resistin and CRP] with total fat mass of the body," suggests the team.

Importantly, no significant associations were found between levels of resistin and presence of the metabolic syndrome or the number of determinants of the metabolic syndrome.

The authors conclude, in the journal Clinical Biochemistry, that prospective studies are required to investigate these associations further.

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By Nikki Withers