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10-01-2018 | Breast cancer | News | Article

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No association between lupus and breast cancer risk

medwireNews: A meta-analysis rules out a direct association between systemic lupus erythematosus (SLE) and breast cancer incidence.

Hassan Mehrad-Majd (Mashhad University of Medical Sciences, Iran) and co-researchers explain that while some recent reports have suggested a decreased breast cancer risk in SLE patients relative to the general population, other studies have been unable to confirm such an association, leading them to conduct a meta-analysis of 18 studies comprising 110,720 SLE patients.

As reported in Clinical Rheumatology, there was no association between SLE and breast cancer incidence, with a nonsignificant relative risk of 1.012 versus the general population. The findings were similar when patients were stratified by factors such as study type, ethnicity, and SLE diagnostic criteria.

Mehrad-Majd et al conclude that “the clinicopathological features of SLE patients may not play a role in susceptibility to breast cancer, compared to the general population,” but caution that the results “should be interpreted in the context of significant heterogeneity among published cohorts.”

By Shreeya Nanda

medwireNews is an independent medical news service provided by Springer Healthcare. © 2018 Springer Healthcare part of the Springer Nature group

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