Perioperative opioid use in US youths often not in line with guidelines
Many children and adolescents are receiving opioid prescriptions for prolonged periods after inpatient or outpatient surgical procedures, which is outside the guidelines for their use, suggests research published in JAMA Network Open.
Surveillance effective for childhood cancer predisposition syndrome management
Early detection of tumours in children with a cancer predisposition syndrome can be achieved with standardised surveillance protocols, US cohort study findings demonstrate.
Blood test predicts Parkinson’s disease up to 7 years before symptom onset
Researchers have used a machine learning approach to create a panel of eight blood biomarkers that can identify people at risk for developing Parkinson’s disease up to 7 years before the first signs or symptoms.
Phoenix Sepsis Score ‘accurate’ for children undergoing cancer treatment
The Phoenix Sepsis Score “accurately” characterises the risk of definitely attributable mortality from sepsis and the duration of intensive care unit stay in children undergoing cancer treatment who have a suspected infection, US researchers report.
Cushing’s syndrome linked to increased cancer risk
Patients with endogenous Cushing’s syndrome have a higher incidence of cancer than the general population, suggests a nationwide cohort study from Taiwan.
Adjuvanted herpes zoster subunit vaccine induces immunity in patients with SLE
The adjuvanted herpes zoster subunit vaccine induces both humoral and cellular immunity in patients with systemic lupus erythematosus, without increasing the risk of disease flare, suggests research from South Korea.
Lipoprotein apheresis improves cardiovascular survival in HoFH
Patients with homozygous familial hypercholesterolaemia who initiate lipoprotein apheresis during childhood and adolescence have a reduced long-term risk for atherosclerotic cardiovascular disease and death, shows follow-up of two international registries.
Pharmacogenomic-guided induction therapy might reduce pediatric AML racial disparities
Using a pharmacogenomic strategy to guide choice of induction therapy for acute myeloid leukaemia might help overcome the disparity in outcomes between Black and White children, suggests research published in JAMA Network Open.
Maralixibat improves itch, bile acid concentrations in paediatric PFIC
Treatment with the ileal bile acid transporter inhibitor maralixibat relieves morning itch for children with different types of progressive familial intrahepatic cholestasis, show phase 3 study findings published in The Lancet Gastroenterology and Hepatology.
Motor benefits for prasinezumab in rapidly progressing early-stage PD
Prasinezumab, a monoclonal antibody that binds aggregated α-synuclein, has shown promise for slowing motor progression in patients with rapidly progressing Parkinson’s disease in a post-hoc analysis of the PASADENA phase 2 study.
