Primary MMR deficiency ‘underdiagnosed’ among young people with glioma
Primary mismatch repair deficiency in gliomas is underdiagnosed among people younger than 40 years old, say investigators who recommend assessment of the biomarker to help facilitate checkpoint inhibitor therapy.
Polygenic risk score predicts Gleason upgrading during active surveillance
A polygenic risk score may help to identify patients undergoing active surveillance for clinically localised prostate cancer who are at particular risk of an increase in their Gleason grade, US research shows.
Omitting axillary biopsy ‘noninferior’ for early-stage breast cancer survival
For women undergoing breast-conserving surgery for invasive breast cancer, omission of axillary sentinel lymph node biopsy offers noninferior 5-year invasive disease-free survival compared with standard axillary surgery, say the INSEMA trial investigators.
Striatum microstructural damage linked to disability and cognitive impairment in ALS
Researchers have identified microstructural damage to the striatum in patients with sporadic amyotrophic lateral sclerosis that could play a key role in the motor disability and cognitive deficits associated with the condition.
Chronic hypercortisolism in CS disrupts circadian genes and rhythmicity of PBMCs
Chronic hypercortisolism in patients with Cushing’s syndrome may disrupt circadian clock genes, which can alter the daily rhythm of immune cell subpopulations beyond remission, suggests research.
Hypertension perseveres from childhood and adolescence to adulthood
High blood pressure or hypertension in childhood or adolescence appears to endure into adulthood, report researchers in findings that support early prevention.
Hypofractionated proton beam therapy regimen feasible for glioblastoma in older patients
A short course of hypofractionated proton beam therapy given alongside temozolomide may offer an improvement in overall survival for patients aged 65 years and older with a new diagnosis of glioblastoma, suggesting findings from a “hypothesis-generating” study.
Regular screening helps reduce symptom burden in paediatric cancer patients
Research shows that young people with a recent diagnosis of cancer benefit from completing an online symptom screening survey three times a week to help direct care.
Routine postoperative imaging may improve pancreatic cancer survival
Research suggests that patients who are invited for routine imaging after pancreatic ductal adenocarcinoma resection have significantly longer overall survival than those who undergo imaging only after the development of symptoms.
Impact of haematological malignancy on pregnancy revealed
Women who are diagnosed with haematological malignancies during pregnancy have similar overall survival to peers diagnosed within a year of their pregnancy ending, indicates research published in The Lancet Haematology.
