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Alzheimer's disease

Alzheimer's disease

05-05-2022 | Neurology | News | Article

TREM2 may have protective effect in Alzheimer’s disease

Researchers have identified an association between faster rates of increase of TREM2 levels in soluble cerebrospinal fluid and slower progression of several markers of disease evolution in participants of the Dominantly Inherited Alzheimer Network, which they say points to a likely protective effect of TREM2 during the early pathogenesis of Alzheimer’s disease.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

11-11-2021 | Neurology | News | Article

Plasma GFAP ‘a sensitive biomarker’ for early amyloid-β pathology

Plasma glial fibrillary acidic protein outperforms its cerebrospinal fluid counterpart in the detection of amyloid-β pathology even in the early stages of Alzheimer’s disease, indicates a cross-sectional study.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

18-10-2021 | Neurology | News | Article

Methylphenidate offers apathy treatment hope for Alzheimer’s disease patients

Methylphenidate is effective for the treatment of apathy in patients with Alzheimer’s disease, suggest study findings published in JAMA Neurology.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

07-02-2019 | Alzheimer's disease | News | Article

Early tau deposition findings support sex differences in AD risk

Researchers have found that clinically healthy women with high amyloid burden have elevated tau deposition compared with men.

24-01-2019 | Alzheimer's disease | News | Article

Frailty plays a key role in dementia risk

Frailty appears to modify the relationship between Alzheimer’s disease pathology and Alzheimer’s dementia, with increased levels making people more susceptible to clinical disease.

13-12-2018 | Neurology | Main feed | News

Biomarkers predict cognitive impairment risk

US researchers have used population-based data to predict an individual’s absolute risk of developing cognitive impairment according to imaging-based biomarkers of amyloid and neuronal injury.

06-12-2018 | Alzheimer's disease | News | Article

Factors predicting misclassification in brief cognitive testing identified

Over a third of patients tested for dementia in the primary care setting may be misclassified due to specific biases in commonly used brief cognitive tests, study findings indicate.

29-11-2018 | Alzheimer's disease | News | Article

Global burden of dementia estimated

The number of people living with dementia globally has more than doubled between 1990 and 2016, estimates the Global Burden of Disease Study 2016.

22-11-2018 | Alzheimer's disease | News | Article

Most patients with Down’s syndrome will have dementia at the time of death

Dementia is the proximate cause of death in 70% of older adults with Down’s syndrome, show findings from a large community-based study published in JAMA Neurology.

15-11-2018 | Alzheimer's disease | News | Article

CSF neurofilament light a ‘preferred’ biomarker for MCI progression

Elevated cerebrospinal fluid neurofilament light levels are associated with an increased risk of mild cognitive impairment, indicate findings from a population-based study.

11-10-2018 | Neurology | News | Article

Anticoagulants could stave off increased risk of dementia associated with AF

Study findings show an increased risk of dementia in older people with atrial fibrillation and support the use of anticoagulants to reduce the likelihood.

20-09-2018 | Alzheimer's disease | News | Article

Flortaucipir PET discriminates AD from other neurodegenerative disorders

The positron emission tomography tracer [18F]flortaucipir could be a useful test for distinguishing Alzheimer’s disease from other neurodegenerative disorders, say researchers.

06-09-2018 | Alzheimer's disease | News | Article

Biomarkers identified for diagnosing AD in patients with Down syndrome

Plasma neurofilament light protein concentrations and cerebrospinal fluid biomarkers are effective for diagnosing Alzheimer’s disease in patients with Down syndrome, say researchers.

05-01-2017 | Neurodegeneration | News | Article

Living close to major roads increases dementia risk

Living close to major roads is associated with an increased risk for dementia, but not for Parkinson’s disease or multiple sclerosis, study findings reported in The Lancet show.

22-12-2016 | Alzheimer's disease | News | Article

Protein in urine linked to dementia risk

Albuminuria is modestly associated with the risk for dementia, researchers report in findings supporting the view that cognitive decline and renal dysfunction may be linked.

21-12-2016 | Alzheimer's disease | News | Article

Anti-tau vaccine for AD shows ‘exceptional immunogenicity’

A first-in-human clinical trial of an active vaccine targeting pathologic tau protein in patients with Alzheimer’s disease has shown the vaccine elicits a well-tolerated, strong, and specific immune response.

13-12-2016 | Alzheimer's disease | News | Article

Gender and ethnicity affect protective role of statins against AD

The potential reduction in Alzheimer’s disease risk afforded by high use of statins varies by statin type, gender, and ethnicity, report researchers.

05-12-2016 | Alzheimer's disease | News | Article

Occupational therapy fails to slow functional decline in Alzheimer’s disease

The addition of 2 years of in-home occupational therapy to collaborative care does not provide functional benefits for patients with Alzheimer’s disease.

01-12-2016 | Alzheimer's disease | News | Article

Amyloid beta present in the hearts of patients with Alzheimer’s disease

Researchers have identified intramyocardial amyloid beta aggregates and changes in cardiac function among patients with Alzheimer’s disease.

30-11-2016 | Alzheimer's disease | News | Article

US dementia decline reported

The prevalence of dementia in the USA has decreased between 2000 and 2012, and increasing educational attainment appears to be one of the contributing factors.