Results of a systematic review suggest that treatment with acetaminophen provides only minimal benefit compared with placebo for patients with osteoarthritis.
The tumor necrosis factor inhibitor certolizumab pegol could be an option for patients with active nonradiographic axial spondyloarthritis and objective signs of inflammation, indicate phase III trial results.
Findings from the KAICA trial suggest that adding ciclosporin to intravenous immunoglobulin treatment may reduce the risk for coronary artery abnormalities among patients with Kawasaki disease.
Using conventional synthetic DMARDs in addition to tumor necrosis factor inhibitor therapy may result in an increased likelihood of clinical response among overweight and obese patients with axial spondyloarthritis, researchers report.
Mortality rates are significantly higher during the first year after a tramadol prescription than after prescription of common nonsteroidal anti-inflammatory drugs, but it is unclear whether the relationship is causal, say researchers.
Findings from a post-hoc pooled analysis suggest that comorbidity does not influence the efficacy or safety of baricitinib 4 mg once daily in patients with rheumatoid arthritis who have had an inadequate response to conventional DMARDs.
A systematic review of consensus recommendations for the management of rheumatoid arthritis in patients with cancer shows agreement in some areas, but highlights the need for further research into topics for which discrepancies exist.
Findings from a systematic review and network meta-analysis indicate that adding sarilumab to conventional DMARDs may be beneficial for patients with rheumatoid arthritis and an inadequate response to either conventional DMARDs or tumor necrosis factor inhibitors.
Initiating the tumor necrosis factor inhibitor golimumab at the same time as methotrexate almost doubles the rate of remission versus methotrexate monotherapy in patients with early psoriatic arthritis, study findings indicate.
The US FDA warns that treatment with the Janus kinase inhibitor tofacitinib at a dose of 10 mg twice daily is associated with an increased risk for pulmonary embolism and death in patients with rheumatoid arthritis.
Maintaining a nonsmoking status for a sustained period is associated with a reduction in the excess risk for developing seropositive rheumatoid arthritis, findings suggest.
The benefits of later-stage exercise programs after total knee replacement are unclear, say researchers, who found a disconnect between patient-reported outcomes and performance-based tests.
Almost half of patients with juvenile idiopathic arthritis have ongoing active disease during early adulthood, with the burden particularly high among those with enthesitis-related arthritis, researchers report.
Individuals with systemic lupus erythematosus who respond to belimumab plus standard of care therapy can hope to experience long-term disease control, suggests a trial in which participants received treatment for up to 13 years.
Patients undergoing unicompartmental knee arthroplasty have shorter hospital stays and fewer early complications than those receiving total knee arthroplasty but are more likely to need a revision within 5 years, results of a large meta-analysis show.
Study findings published in The BMJ suggest that the risk for serious adverse events following shoulder replacement surgery is greater than previously considered, and the likelihood of requiring revision surgery is elevated in younger patients.