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Asthma

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04-09-2017 | Asthma | News | Article

Japanese subphenotypes of type 2 severe asthma identified

The majority of Japanese patients with severe, difficult-to-treat asthma are likely to present with type 2 asthma and a substantial proportion overlap between two or more subphenotypes, a study suggests.

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J Allergy Clin Immunol Pract 2017; Advance online publication

04-09-2017 | Asthma | News | Article

Gene profiles differ in adult- and childhood-onset severe asthma

A European study suggests gene profiles differ in severe asthma that begins in adulthood rather than childhood, indicating distinct underlying mechanisms at work.

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J Allergy Clin Immunol 2017; Advance online publication

04-09-2017 | Asthma | Highlight | Article

Editor's pick

Global decline in asthma deaths may have stalled

Death rates from asthma among younger people appear to have plateaued in the past decade despite substantial improvements before this, a study in The Lancet suggests.

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Lancet 2017; Advance online publication

09-08-2017 | Asthma | News | Article

Point-of-care device shows promise for blood eosinophil count in severe asthma

Study findings validate a point-of-care device for assessing blood eosinophils that could help in the management of severe asthma.

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Ann Allergy Asthma Immunol 2017; 119: 16–20

09-08-2017 | Asthma | News | Article

Asthma phenotypes change with age

Researchers have found that older patients with asthma have different phenotypes to those of younger patients.

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Respirology 2017; Advance online publication

09-08-2017 | Asthma | News | Article

Editor's pick

Obesity impacts eosinophilia biomarker sensitivity

Markers of inflammation conventionally used to identify eosinophilic airway inflammation in patients with asthma may not be effective in obese individuals, research suggests.

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J Allergy Clin Immunol 2017; Advance online publication

17-07-2017 | Asthma | News | Article

QoL measure gives the asthma patient’s perspective

Researchers have devised a new measure for assessing the effect of asthma on quality of life from the patient’s perspective.

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J Allergy Clin Immunol 2017; Advance online publication

04-07-2017 | Asthma | News | Article

Considerable health burden for patients with poorly controlled asthma

Study findings show a high prevalence of poorly controlled asthma among patients treated with inhaled corticosteroid and long-acting beta-agonist combination therapy, highlighting poor treatment adherence or an unmet need in current treatment.

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J Asthma 2017; Advance online publication

04-07-2017 | Asthma | News | Article

Regulatory pathway revealed for ILC2-mediated pulmonary inflammation

Suppression of type 2 innate lymphoid cells by activated plasmacytoid dendritic cells could present a regulatory pathway for pulmonary inflammation, early research suggests.

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J Allergy Clin Immunol 2017; Advance online publication

03-07-2017 | Asthma | News | Article

Editor's pick

Surrogate endpoint for severe asthma exacerbations could facilitate drug trials

Researchers have devised a composite, surrogate endpoint – CompEx – that strongly mirrors severe asthma exacerbation response to treatment, but can be measured earlier in the trial process and in smaller patient samples.

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Lancet Respir Med 2017; 5: 539–540, 577–590

14-06-2017 | Asthma | News | Article

Structured management of overall health recommended for difficult-to-treat asthma

Researchers have found that a structured approach to managing specialist-referred patients with difficult-to-treat asthma, which includes assessing and treating associated comorbidities, improves symptom control and reduces exacerbation frequency.

Source:

J Allergy Clin Immunol Pract 2017; Advance online publication

14-06-2017 | Asthma | News | Article

Editor's pick

Prior asthma exacerbations predict future risk

The risk for moderate or severe asthma exacerbations is primarily predicted by the occurrence of prior corresponding exacerbations, shows research.

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BMC Pulm Med 2017; 17: 77

15-05-2017 | Asthma | News | Article

Editor's pick

Multivariate model predicts eosinophilic asthma without sputum induction

Researchers have designed a multivariate prediction model for identifying eosinophilic asthma that uses the activation state of peripheral blood eosinophils rather than sputum analysis.

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Allergy 2017; Advance online publication

15-05-2017 | Asthma | News | Article

Sputum eosinophils may help guide asthma control

Individual fluctuations in eosinophilic inflammation are associated with asthma control, show data from patients in daily practice.

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J Allergy Clin Immunol Pract 2017; Advance online publication

18-04-2017 | Asthma | News | Article

Clinical score predicts risk of severe asthma exacerbation trajectory

Researchers have devised and validated a clinical risk score that accurately identifies asthma patients who will have persistently frequent severe exacerbations over the long term.

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Allergy 2017; Advance online publication

18-04-2017 | Asthma | News | Article

Editor's pick

Many patients fail to achieve good asthma control despite stepped treatment optimization

Stepped increases to optimize treatment improve asthma control, but for many patients optimal control still remains elusive, suggest findings from the real-life COAS study.

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Eur Respir J 2017; 49: 1501885

18-04-2017 | Asthma | News | Article

Asthma exacerbations reliably predict future risk

A history of asthma exacerbation is a reliable indicator of future risk for exacerbations, say Japanese researchers.

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Allergol Int 2017; Advance online publication

20-03-2017 | Asthma | News | Article

Th2 molecular phenotypes defined for severe asthma

Researchers have defined three molecular phenotypes of asthma, based on T-helper cell type 2 status, which could help better target specific treatments.

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Eur Respir J 2017; 49: 1602135, 1700053

13-02-2017 | Asthma | News | Article

Eosinophilic airway inflammation and microbiome link

Eosinophilic airway inflammation in patients with asthma is associated with an altered microbiome in the lower airway, report researchers.

Source:

J Allergy Clin Immunol 2017; Advance online publication

13-02-2017 | Asthma | News | Article

Biomarkers aid Type-2 inflammation phenotype selection

Researchers have identified a panel of clinically accessible biomarkers that may help select asthma patients with an airway-mucosal T-helper 2 inflammation phenotype.

Source:

J Allergy Clin Immunol 2017; Advance online publication

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