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The independent medical news service

Colorectal cancer

23-04-2019 | Oncology | News | Article

SABR may improve survival in oligometastatic cancer

The phase II SABR-COMET study has indicated that stereotactic ablative radiotherapy prolongs overall and progression-free survival versus palliative treatment in patients with up to five oligometastases.

01-02-2019 | Colorectal cancer | News | Article

EMA gives biosimilar bevacizumab positive opinion

Read more on this decision here

29-11-2018 | Colorectal cancer | News | Article

Rechallenge with cetuximab, irinotecan may benefit mCRC patients

Approximately one-fifth of patients with RAS and BRAF wild-type metastatic colorectal cancer derive clinical benefit from rechallenge with cetuximab plus irinotecan, Italian researchers report.

06-11-2018 | Oncology | Main feed | News

Run-in period may improve adherence to aspirin for chemoprevention

In patients undergoing radical therapy for cancer, an 8-week run-in period of aspirin is acceptable and well tolerated, and could reduce the risk for nonadherence and participant attrition in adjuvant and prevention trials, say researchers.

11-10-2018 | Oncology | Main feed | News

Screen-detected colon cancer patients experience fewer complications

Patients whose colon cancers are detected by routine screening have fewer postoperative complications than individuals whose cancers are diagnosed outside of a national programme, study findings indicate.

01-08-2018 | Oncology | News | Article

Benefits of laparoscopic surgery for colorectal liver metastases highlighted

Minimally invasive liver surgery is associated with less postoperative morbidity, fewer major complications, and shorter hospital stays than open surgery among patients with colorectal liver metastases, Italian researchers report.

03-07-2018 | Colorectal cancer | Main feed | News

Fruquintinib prolongs metastatic CRC survival

Phase III trial results indicate that third- or later-line treatment with fruquintinib leads to significantly improved overall survival in Chinese patients with metastatic colorectal cancer.

29-06-2018 | Colorectal cancer | News | Article

In other news: CRC and surveillance

We cover three studies of colorectal cancer surveillance, one evaluating the relationship between adenomas at colonoscopy and the long-term incidence of cancer, while the other two investigate whether higher-intensity post-surgery follow-up improves outcomes.

14-06-2018 | Colorectal cancer | News | Article

Oxaliplatin HIPEC unnecessary for colorectal peritoneal carcinomatosis patients

Oxaliplatin-based hyperthermic intraperitoneal chemotherapy after cytoreductive surgery does not improve the survival of colorectal cancer patients with peritoneal carcinomatosis, the PRODIGE 7 investigators report.

02-06-2018 | Colorectal cancer | News | Article

Metastatic CRC cost disparity revealed for USA, Canada

The cost of metastatic colorectal cancer treatment in the USA is significantly more expensive than in Canada but does not achieve a greater survival benefit among patients, highlight findings reported at the ASCO Annual Meeting 2018 in Chicago, Illinois, USA.

29-05-2018 | Colorectal cancer | News | Article

Sex differences highlighted for CRC chemotherapy-related toxicity

Women have an increased risk for adverse events associated with fluorouracil-based chemotherapy for colorectal cancer, suggests an analysis of the PETACC-3 trial.

25-05-2018 | Colorectal cancer | News | Article

Worse prognosis for patients with V600E BRAF-mutated colorectal liver metastases

The presence of the BRAF V600E mutation in colorectal liver metastases is associated with a worse prognosis and increased risk for recurrence, according to findings from an international retrospective cohort study.

04-04-2018 | Colorectal cancer | News | Article

mXELIRI regimen offers alternative treatment for metastatic colorectal cancer

Treatment with a modified XELIRI regimen offers an alternative to standard second-line therapy with FOLFIRI in patients with metastatic colorectal cancer, research conducted in Asia shows.

21-03-2018 | Oncology | News | Article

EU mortality rates predicted to decline for many tumor types

Mortality rates associated with most of the major cancer sites are expected to decline in the European Union in 2018, research indicates.

14-02-2018 | Oncology | News | Article

Early alpelisib data promising in patients with PIK3CA-altered solid tumors

Researchers report “encouraging” tolerability and efficacy results from a phase Ia trial of the oral phosphatidylinositol 3-kinase α–selective inhibitor alpelisib among patients with PIK3CA-altered advanced solid tumors.

05-02-2018 | Colorectal cancer | News | Article

Nivolumab–ipilimumab duo has potential for dMMR/MSI-H metastatic CRC

CheckMate 142 findings point to a role for dual PD-1 and CTLA-4 inhibition with nivolumab and ipilimumab in patients with previously treated metastatic colorectal cancer that is DNA mismatch repair-deficient or has high microsatellite instability.

25-01-2018 | Colorectal cancer | News | Article

Regular PET/CT imaging fails to extend high-risk CRC patient survival

Researchers do not recommend the addition of 18F-fluorodeoxyglucose–positron emission tomography/computed tomography to a standard 3-year monitoring strategy for patients with stage II perforated, stage III, or stage IV colorectal cancer at high risk for recurrence.

24-01-2018 | Colorectal cancer | News | Article

No advantage to continuing bevacizumab after induction chemotherapy in mCRC

Maintenance treatment with bevacizumab monotherapy following induction chemotherapy has no benefit for metastatic colorectal cancer patients, PRODIGE 9 trial findings show.

19-01-2018 | Colorectal cancer | News | Article

Inflammatory diet linked to CRC risk

A diet rich in foods with a high inflammatory potential is associated with a significant increase in the risk for colorectal cancer, say US researchers who collated information from more than 120,000 adults followed up over 26 years.

16-11-2017 | Colorectal cancer | News | Article

Mismatch repair deficiency testing underused for CRC patients in USA

Researchers have warned that underuse of mismatch repair deficiency testing “is a persistent and pervasive problem” in the USA, even among young adults with colorectal cancer where its use is unequivocally recommended.

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