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Neurology

Most patients with Down’s syndrome will have dementia at the time of death

Down's syndrome karyotype

Dementia is the proximate cause of death in 70% of older adults with Down’s syndrome, show findings from a large community-based study published in JAMA Neurology.

Oncology

Risk for severe irAEs noted with sequential PD-1/PD-L1 blockade and osimertinib

Pills and water (symbolic image with model)

Patients with advanced EGFR mutation-positive non-small-cell lung cancer who receive osimertinib directly after agents targeting PD-1 or PD-L1 may be at increased risk for developing severe immune-related adverse events, suggests a chart review.

Ophthalmology

Intravitreal injection linked to substantial temporary blood pressure increase

Syringe

Patients undergoing intravitreal injections with anti–vascular endothelial growth factor agents can experience substantial transient increases in systolic blood pressure, Swiss researchers report.

Respiratory

Chronic cough may point to more severe asthma phenotype

Cough (symbolic image with model)

Among patients with asthma, those with chronic cough have worse respiratory symptoms and lung function, and higher levels of some inflammatory markers, than those without, study findings indicate.

Rheumatology

Certolizumab pegol shows promise for nonradiographic axSpA

Spine

The tumor necrosis factor inhibitor certolizumab pegol could be an option for patients with active nonradiographic axial spondyloarthritis and objective signs of inflammation, indicate phase III trial results.

Headlines from across medwireNews

21-03-2019 | Ophthalmology | News | Article

CD11b-positive monocytes could help guide anti-VEGF treatment in CNV diseases

Measuring CD11b-positive monocytes could help estimate how many anti-vascular endothelial growth factor injections a patient with neovascular age-related macular degeneration or polypoidal choroidal vasculopathy might need, study findings suggest.

21-03-2019 | Respiratory | News | Article

Pirfenidone a ‘feasible treatment option’ for advanced IPF

A post-hoc analysis of the RECAP study suggests that pirfenidone-treated patients with idiopathic pulmonary fibrosis experience similar rates of lung function decline irrespective of whether they have more or less advanced disease.

21-03-2019 | Rheumatology | News | Article

Progressive skin fibrosis should trigger enhanced monitoring in dcSSc

Progressive skin fibrosis is significantly associated with worsening lung function and an increased risk for death among patients with diffuse cutaneous systemic sclerosis, an analysis of EUSTAR data shows.

21-03-2019 | Oncology | Main feed | News

Second-line atezoliumab feasible for advanced urothelial carcinoma with comorbidity

Results from the SAUL study add support for the use of atezolizumab in patients with advanced urothelial or nonurothelial carcinoma of the urinary tract, including those with autoimmune disease and other comorbidities.

21-03-2019 | Diabetes | News | Article

Microvascular disease a marker of heart failure risk in type 2 diabetes

The presence of microvascular disease in people with type 2 diabetes signals a high risk for heart failure, report the EMPA-REG OUTCOME investigators.

20-03-2019 | Rheumatology | News | Article

RA disease activity linked to cognitive impairment

Rheumatoid arthritis patients with high disease activity are more likely to have cognitive impairment than those with less active disease, researchers report.

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