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Pain affects almost nine in every 10 people with systemic sclerosis, with multiple disease-related factors potentially contributing to pain intensity, researchers report.

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The tyrosine kinase inhibitor poziotinib has antitumor activity in heavily pretreated patients with advanced or metastatic non-small-cell lung cancer harboring HER2 exon 20 insertions, show data from the phase 2 ZENITH20 trial.

Among pregnant women with preexisting diabetes, those with nephropathy or retinopathy may be at increased risk for pregnancy complications, suggest findings from a systematic review and meta-analysis.

A meta-analysis carried out by the COVID-19 Global Rheumatology Alliance suggests that people with rheumatic and musculoskeletal diseases have a higher risk for SARS-CoV-2 infection and mortality than the general population.

A pooled analysis of the DAPA-HF and DAPA-CKD trials suggests that taking the SGLT2 inhibitor dapagliflozin reduced the participants’ risk for developing type 2 diabetes by around a third.