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Rheumatology

ACR/NPF guidelines for the treatment of PsA published

Guidelines

The American College of Rheumatology and the National Psoriasis Foundation have issued evidence-based guidelines for the pharmacologic and nonpharmacologic treatment of active psoriatic arthritis.

Neurology

Most patients with Down’s syndrome will have dementia at the time of death

Down's syndrome karyotype

Dementia is the proximate cause of death in 70% of older adults with Down’s syndrome, show findings from a large community-based study published in JAMA Neurology.

Respiratory

Slow gait speed predicts poor prognosis in patients with IPF

Older people walking

Study findings suggest that slow gait speed is significantly associated with an increased risk of mortality and hospitalisation among patients with idiopathic pulmonary fibrosis .

Oncology

Direct oral anticoagulants AVERT VTE events in patients with cancer

Blood clot

The results of the randomized CASSINI and AVERT trials support the prophylactic use of the direct oral anticoagulants rivaroxaban and apixaban in cancer patients undergoing chemotherapy who are at risk for venous thromboembolism events.

Ophthalmology

Intravitreal injection linked to substantial temporary blood pressure increase

Syringe

Patients undergoing intravitreal injections with anti–vascular endothelial growth factor agents can experience substantial transient increases in systolic blood pressure, Swiss researchers report.

Headlines from across medwireNews

14-12-2018 | Small-cell lung cancer | News | Article

Veliparib shows efficacy in some patients with extensive-stage SCLC

Some patients with extensive-stage small-cell lung cancer may benefit from the addition of the poly(ADP ribose) polymerase inhibitor veliparib to standard chemotherapy, but further confirmation of its efficacy is needed, say researchers.

14-12-2018 | Rheumatology | News | Article

Support for abatacept–methotrexate combination therapy in RA patients

Adding abatacept to methotrexate improves disease activity and reduces structural progression among ACPA-positive rheumatoid arthritis patients with early erosion, Japanese researchers report.

13-12-2018 | Ophthalmology | Main feed | News

Predictors of poor outcome with anti-VEGF therapy identified for nAMD

Researchers from the Fight Retinal Blindness! study group have identified a number of variables that predict of sustained loss of visual acuity in patients with neovascular age-related macular degeneration.

13-12-2018 | Neurology | Main feed | News

Biomarkers predict cognitive impairment risk

US researchers have used population-based data to predict an individual’s absolute risk of developing cognitive impairment according to imaging-based biomarkers of amyloid and neuronal injury.

13-12-2018 | Breast cancer | News | Article

Trastuzumab emtansine targets residual invasive HER2-positive breast cancer

Adjuvant trastuzumab emtansine halves the risk of invasive disease recurrence or death versus trastuzumab in patients with residual invasive human epidermal growth factor receptor 2-positive early breast cancer, researchers report.

13-12-2018 | Rheumatology | News | Article

Mortality predictors identified in patients with giant cell arteritis

Patients with large vessel involvement when diagnosed with biopsy-confirmed giant cell arteritis have a substantially increased risk of death relative to patients with no large vessel involvement, Italian researchers report.

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