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Rheumatology

Tocilizumab not linked to elevated cardiovascular risk in RA patients

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Patients with rheumatoid arthritis who are treated with tocilizumab have a similar cardiovascular risk profile to those taking most other biological DMARDs, results of a real-world study suggest.

Respiratory

Proportion of asthma patients who could benefit from anti-IL-5 treatment estimated

Antibodies

Researchers estimate that 2% of patients with adult-onset eosinophilic asthma could benefit from treatment involving antibodies against the interleukin-5 pathway.

HBV

Global HBV prevalence estimated at 3.9%

World map

More than 290 million people, or 3.9% of the global population, are infected with hepatitis B virus, and while efforts to combat infection are improving, greater access to diagnosis and treatment is needed to meet global targets, report The Polaris Observatory Collaborators.

Neurology

Ibudilast slows brain shrinkage in progressive multiple sclerosis patients

MRI brain scan

Ibudilast may slow brain atrophy in patients with progressive multiple sclerosis, show findings from a phase II study.

Oncology

Meta-analysis consolidates evidence against PSA-based screening

PSA test

Prostate-specific antigen-based screening may lead to a modest reduction in prostate cancer-specific mortality but has no effect on overall survival, say the authors of a meta-analysis published in The BMJ.

Headlines from across medwireNews

20-09-2018 | Rheumatology | News | Article

Difficult-to-treat RA characteristics vary among rheumatologists

The perceived characteristics of difficult-to-treat rheumatoid arthritis vary widely among rheumatologists, and are often not addressed by current EULAR management recommendations, shows an Annals of the Rheumatic Diseases report.

20-09-2018 | Lymphoma | News | Article

Hormonal biomarker shows ovarian toxicity of Hodgkin lymphoma treatment

Phase III trial data have highlighted the value of antimüllerian hormone as a biomarker of ovarian toxicity associated with different chemotherapy regimens for advanced Hodgkin lymphoma.

20-09-2018 | Oncology | Main feed | News

Hairy cell leukemia cytotoxin therapy approved by FDA

More information on this announcement here

20-09-2018 | Alzheimer's disease | News | Article

Flortaucipir PET discriminates AD from other neurodegenerative disorders

The positron emission tomography tracer [18F]flortaucipir could be a useful test for distinguishing Alzheimer’s disease from other neurodegenerative disorders, say researchers.

20-09-2018 | Oncology | Main feed | News

Early atezolizumab results point to potential role in metastatic TNBC care

Phase I trial findings suggest that patients with metastatic triple-negative breast cancer might benefit from treatment with the programmed cell death ligand 1 inhibitor atezolizumab.

19-09-2018 | Oncology | News | Article

Persistent mutations post-transplant predict MDS disease progression

Persistent disease-associated mutations detected in the bone marrow 30 days after stem cell transplantation are associated with an increased risk for disease progression among patients with myelodysplastic syndrome, research shows.

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