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- Oncology |
- Paediatrics |
Primary MMR deficiency ‘underdiagnosed’ among young people with glioma
Primary mismatch repair deficiency in gliomas is underdiagnosed among people younger than 40 years old, say investigators who recommend assessment of the biomarker to help facilitate checkpoint inhibitor therapy.
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- Oncology |
Polygenic risk score predicts Gleason upgrading during active surveillance
A polygenic risk score may help to identify patients undergoing active surveillance for clinically localised prostate cancer who are at particular risk of an increase in their Gleason grade, US research shows.
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- Oncology |
Omitting axillary biopsy ‘noninferior’ for early-stage breast cancer survival
For women undergoing breast-conserving surgery for invasive breast cancer, omission of axillary sentinel lymph node biopsy offers noninferior 5-year invasive disease-free survival compared with standard axillary surgery, say the INSEMA trial investigators.
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- Neurology |
Striatum microstructural damage linked to disability and cognitive impairment in ALS
Researchers have identified microstructural damage to the striatum in patients with sporadic amyotrophic lateral sclerosis that could play a key role in the motor disability and cognitive deficits associated with the condition.
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- Endocrinology |
Chronic hypercortisolism in CS disrupts circadian genes and rhythmicity of PBMCs
Chronic hypercortisolism in patients with Cushing’s syndrome may disrupt circadian clock genes, which can alter the daily rhythm of immune cell subpopulations beyond remission, suggests research.
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- cardiology |
- hypertension |
- Paediatrics |
Hypertension perseveres from childhood and adolescence to adulthood
High blood pressure or hypertension in childhood or adolescence appears to endure into adulthood, report researchers in findings that support early prevention.
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