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Asthma

Eosinophilia linked to lung function decline irrespective of asthma symptoms

Blood sample

High blood eosinophil counts are associated with airflow obstruction and lung function decline in patients with asthma, but also in people without respiratory symptoms, population-based study findings show.

HBV

Updated AASLD guidance released on HBV prevention, diagnosis, and treatment

Folder_Binders in background

The American Association for the Study of Liver Diseases has issued a guidance statement for chronic hepatitis B virus, covering topics ranging from screening and prevention through to the clinical management of patients.

Oncology

Need for nephrectomy challenged in some sunitinib-treated metastatic renal cancers

Human kidney cross section

Results of the phase III CARMENA trial show that treatment with sunitinib alone is as good as treatment with nephrectomy followed by sunitinib in patients with intermediate- or poor-risk metastatic renal cell carcinoma.

Rheumatology

Diclofenac linked to increased myocardial infarction risk in SpA patients

Heartbeat

Current use of the nonsteroidal anti-inflammatory drug diclofenac, but not of naproxen, is associated with a threefold increased risk for myocardial infarction among individuals with spondyloarthritis, according to recent findings.

Headlines from across medwireNews

22-06-2018 | ASCO | Main feed | News

Avelumab–lorlatinib shows efficacy for heavily pretreated ALK-positive NSCLC

The JAVELIN Lung 101 study suggests that the PD-L1 inhibitor avelumab plus the third-generation ALK inhibitor lorlatinib may be a feasible combination in non-small-cell lung cancer patients with heavily pretreated, advanced ALK-positive disease.

22-06-2018 | Breast cancer | News | Article

Mixed results for denosumab for the prevention of breast cancer recurrence

Two opposing sets of phase III results regarding the effect of denosumab on the recurrence of hormone receptor-positive nonmetastatic breast cancer have been presented at the ASCO Annual Meeting 2018 in Chicago, Illinois, USA.

21-06-2018 | ASCO | Main feed | News

Maintenance therapy boosts high-risk pediatric rhabdomyosarcoma survival

A significant overall survival benefit with the use of maintenance chemotherapy has been demonstrated by the RMS2005 trial of children who have completed standard treatment for high-risk, nonmetastatic rhabdomyosarcoma.

20-06-2018 | Asthma | News | Article

Good prognosis for patients with mild asthma

Research findings can reassure patients with mild asthma that the long-term prognosis is good, with only a tenth of patients transitioning to more severe disease over 10 years.

20-06-2018 | Rheumatology | News | Article

Abatacept fails to boost renal response rate in lupus nephritis

The addition of abatacept to standard therapy does not increase the rate of complete renal response among patients with lupus nephritis, phase III study findings show.

20-06-2018 | Rheumatology | News | Article

No increase in JIA-associated uveitis risk with etanercept treatment

Patients with juvenile idiopathic arthritis who are treated with etanercept do not have a higher risk for developing uveitis than those given methotrexate, results of a UK cohort study suggest.

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