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Asthma

Airway type 2 inflammation refractory to corticosteroids in many severe asthma patients

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Airway type 2 inflammation is not fully suppressed in around half of asthma patients despite receipt of inhaled corticosteroid treatment, study findings show.

HBV

ACP, CDC issue HBV vaccination, screening best practice advice

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The American College of Physicians and Centers for Disease Control and Prevention have released best practice guidance for hepatitis B virus vaccination, screening, and linkage to care.

Oncology

Adjuvant chemotherapy duration in stage III colon cancer: One size does not fit all

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The optimal duration of adjuvant chemotherapy in patients with stage III colon cancer may depend on the regimen used and the patient’s risk status, indicate the results of the international IDEA collaboration.

Rheumatology

Recommendations for treating JIA-associated uveitis published

Guidelines

The SHARE initiative has developed consensus evidence-based recommendations for the treatment of uveitis associated with juvenile idiopathic arthritis.

Headlines from across medwireNews

19-04-2018 | Oncology | News | Article

Targeted inhibitor shows potential for RET-altered solid tumors

A selective inhibitor of the receptor tyrosine kinase RET could benefit patients with tumors harboring alterations in the oncogene, suggest early results presented at the American Association for Cancer Research Annual Meeting 2018.

19-04-2018 | Rheumatology | News | Article

‘Reassuring’ data on certolizumab pegol use during pregnancy

Treatment with the tumor necrosis factor inhibitor certolizumab pegol during pregnancy is not likely to be associated with teratogenic effects, researchers report.

18-04-2018 | Non-small-cell lung cancer | News | Article

Nivolumab plus ipilimumab benefits shown in highly mutated advanced NSCLC

CheckMate-227 shows that treatment with nivolumab plus ipilimumab significantly improves progression-free survival compared with chemotherapy in patients with advanced non-small-cell lung cancer and a high tumor mutational burden.

18-04-2018 | Rheumatology | News | Article

Further evidence for sustained benefits of adalimumab in axSpA

Extension results from the ABILITY-1 trial support the long-term benefits of adalimumab for patients with nonradiographic axial spondyloarthritis.

17-04-2018 | Rheumatology | News | Article

High TNF inhibitor retention rate in SpA patients

Researchers have found that the long-term retention rate for a first tumor necrosis factor inhibitor is favorable in patients with spondyloarthritis.

17-04-2018 | Melanoma | News | Article

Pembrolizumab delays recurrence in high-risk stage III melanoma

Adjuvant pembrolizumab significantly improves recurrence-free survival, compared with placebo, when given to patients with high-risk stage III melanoma for up to 1 year, researchers report in The New England Journal of Medicine.

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