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Neurology

Most patients with Down’s syndrome will have dementia at the time of death

Down's syndrome karyotype

Dementia is the proximate cause of death in 70% of older adults with Down’s syndrome, show findings from a large community-based study published in JAMA Neurology.

Oncology

Darolutamide reduces CRPC metastasis risk

Older man taking pill

Addition of the androgen receptor antagonist darolutamide to androgen deprivation therapy improves metastasis-free survival in patients with castration-resistant prostate cancer, indicate ARAMIS trial results.

Ophthalmology

Intravitreal injection linked to substantial temporary blood pressure increase

Syringe

Patients undergoing intravitreal injections with anti–vascular endothelial growth factor agents can experience substantial transient increases in systolic blood pressure, Swiss researchers report.

Respiratory

Asthma remains a ‘significant healthcare burden’

Asthma medication

An analysis of electronic primary care records indicates that the prevalence of asthma continues to be high in the UK, with an increasing proportion of patients treated with inhaled corticosteroids.

Rheumatology

Longevity of hip, knee replacements in OA patients estimated

Knee arthroplasty concept image (symbolic image with model)

Two meta-analyses published in The Lancet provide estimates for how long hip and knee replacements are likely to last in patients with osteoarthritis.

Headlines from across medwireNews

22-02-2019 | Prostate cancer | News | Article

CheckMate 650: Nivolumab–ipilimumab potential for mCRPC demonstrated

The combination of nivolumab and ipilimumab has antitumor activity in men with metastatic castration-resistant prostate cancer, suggest CheckMate 650 data.

22-02-2019 | Rheumatology | News | Article

FDA warns of increased death risk with febuxostat

The US FDA will update the prescribing information for the gout treatment febuxostat to include a boxed warning for death risk.

22-02-2019 | Rheumatology | News | Article

EMA gives nod to two adalimumab biosimilars

The Committee for Medicinal Products for Human Use has recommended two new adalimumab biosimilars for approval in Europe.

21-02-2019 | Diabetes | News | Article

Quality of care may influence risk factors for diabetes complications

Poorer quality of care is linked to greater variability in clinical parameters associated with the risk for complications among patients with type 2 diabetes, researchers report.

21-02-2019 | Kidney cancer | News | Article

Immunotherapy-based regimens show promise in non-clear-cell RCC

Three trials point to the potential of regimens incorporating agents targeting the programmed cell death protein 1 or its ligand in patients with non-clear-cell renal cell carcinoma.

21-02-2019 | Ophthalmology | News | Article

Biphasic oxygen targets help prevent retinopathy of prematurity

Biphasic oxygen targets can decrease the incidence and severity of retinopathy of prematuritywithout increasing the risk of death, cohort study findings suggest.

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