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Rheumatology

Gene expression profiling points to methotrexate nonresponders

DNA

Rheumatoid arthritis patients who are unlikely to respond to methotrexate could be identified based on their gene expression profiles before and 4 weeks after initiating treatment, say researchers.

Neurology

Most patients with Down’s syndrome will have dementia at the time of death

Down's syndrome karyotype

Dementia is the proximate cause of death in 70% of older adults with Down’s syndrome, show findings from a large community-based study published in JAMA Neurology.

Respiratory

Most patients with asthma will not experience an exacerbation

Asthma attack_woman

Only a third of patients with asthma will experience an exacerbation, show 7 years of observation in more than 50,000 adults with the condition.

Oncology

Prolonged OS possible for ALK-positive stage IV NSCLC

DNA_cancer cell

Individuals with stage IV non-small-cell lung cancer harboring anaplastic lymphoma kinase translocations can hope to achieve overall survival of nearly 7 years, suggests a US cohort analysis.

Ophthalmology

Intravitreal injection linked to substantial temporary blood pressure increase

Syringe

Patients undergoing intravitreal injections with anti–vascular endothelial growth factor agents can experience substantial transient increases in systolic blood pressure, Swiss researchers report.

Headlines from across medwireNews

22-01-2019 | Diabetes | News | Article

Oral basal insulin not yet commercially viable despite good glycemic control

Oral insulin 338, a long-acting basal insulin analog, provides similar glycemic control to that achieved with insulin glargine among insulin-naive patients with type 2 diabetes, phase II study data show.

22-01-2019 | Oncology | News | Article

Mutational load predicts immunotherapy response across most tumor types

Tumor mutational burden could be a cross-tumor predictive biomarker of immunotherapy, say US researchers who found an association between mutational load and survival across a wide range of malignancies treated with immune checkpoint inhibitors.

21-01-2019 | Diabetes | News | Article

Poor glycemic control has diabetes type-specific effect on fracture risk

Poor glycemic control is associated with an increased risk for low-trauma fracture in people with type 1, but not type 2, diabetes, study findings indicate.

21-01-2019 | Kidney cancer | News | Article

Sustained benefit of VEGFR–TKIs after doublet immunotherapy in metastatic RCC

Second-line treatment with vascular endothelial growth factor receptor–tyrosine kinase inhibitors after failure of nivolumab plus ipilimumab continues to benefit patients with metastatic renal cell carcinoma, report researchers.

21-01-2019 | Rheumatology | News | Article

Trial results back TNF inhibitor dose-reduction strategy in ankylosing spondylitis patients

A dose-reduction strategy may be feasible for ankylosing spondylitis patients in sustained clinical remission with tumor necrosis factor inhibitor treatment, findings from the open-label REDES-TNF trial suggest.

18-01-2019 | Kidney cancer | News | Article

Potential ‘risk of harm’ for older women with adjuvant sunitinib for RCC

Adjuvant treatment with sunitinib may be associated with an increased mortality risk for older female patients with renal cell carcinoma, suggests a post-hoc analysis of the ASSURE trial that compared sunitinib and sorafenib with placebo.

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