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Surrogate endpoint for severe asthma exacerbations could facilitate drug trials

Man_peak flow meter

Researchers have devised a composite, surrogate endpoint – CompEx – that strongly mirrors severe asthma exacerbation response to treatment, but can be measured earlier in the trial process and in smaller patient samples.


Overt, occult HBV infection remains a concern despite immunization


Despite a universal program to vaccinate newborns against hepatitis B virus infection, the prevalence of overt and occult infection among children in northwest China is a cause for concern, say researchers.


Mid-spectrum melanoma diagnoses have low reproducibility, accuracy


A study of US pathologists highlights the difficulties of diagnosing melanocytic skin lesions, finding low levels of intra- and interobserver reproducibility and accuracy in diagnoses ranging from moderately dysplastic nevi to early-stage invasive melanoma.


Updated treatment targets for axial and peripheral spondyloarthritis


An international taskforce has developed updated recommendations on therapeutic targets for spondyloarthritis in light of evidence from the past 5 years.

Headlines from across medwireNews

21-07-2017 | Non-small-cell lung cancer | News | Article

Hair repigmentation points to NSCLC immunotherapy response

Spanish researchers who observed hair repigmentation among patients with non-small-cell lung cancer who responded to immunotherapeutic drugs against programmed cell death protein 1 and its ligand believe that the side effect could serve as a potential marker of response.

21-07-2017 | Rheumatology | News | Article

Predictors of infection risk identified in RA patients treated with tocilizumab

High neutrophil counts, leflunomide treatment, and the absence of anti-citrullinated protein antibodies are associated with increased risk for serious infection among patients with rheumatoid arthritis who are treated with tocilizumab, researchers report.

20-07-2017 | Rheumatology | News | Article

Stopping TNF inhibitor treatment has short-term negative impact for RA patients

Patients with rheumatoid arthritis who stop tumor necrosis factor inhibitor therapy experience worse patient-reported outcomes in the short-term than those who continue treatment, analysis of trial data suggests.

20-07-2017 | Oncology | News | Article

Rare cancer rates measured in Europe

Nearly a quarter of all cancers diagnosed in the European Union between 2000 and 2007 were classed as rare, according to updated epidemiologic information from the Information Network on Rare Cancers.

19-07-2017 | Breast cancer | News | Article

Genetic test identifies ultralow-risk breast cancers

The 70-gene MammaPrint assay can identify women who have an ultralow risk for death from breast cancer in the long term, potentially allowing their physicians to choose less aggressive treatment, say researchers.

18-07-2017 | Prostate cancer | News | Article

PIVOT: No survival benefit with surgery over observation in localized prostate cancer

All-cause and prostate cancer-specific mortality rates remain comparable over nearly 2 decades of follow-up among men with early prostate cancer regardless of whether they undergo radical prostatectomy or observation, the PIVOT trial shows.

Beyond the news


medwireNews brings you news and conference reports from the ESMO 2016 Congress, held in Copenhagen, Denmark.

Click through to read the full reports of the latest research.

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Visit our dedicated microsite for research news, interviews and in-depth analysis of paediatric endocrinology and growth disorders.


Highlights from the 1st conference of the European Academy of Neurology in Berlin, Germany.

Click through to read research news from the conference.

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