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Cardiology

Oral thrombin inhibitor treatment could increase blood clot formation

Blood clot

The oral thrombin inhibitor dabigatran may actually increase thrombus formation, suggest the results of a translational study conducted in human arterial plaque and mouse models of blood clotting.

Neurology

‘New dawn’ for spinal muscular atrophy treatment

Baby_grasping toe

Nusinersen has shown promise as a treatment for infantile-onset spinal muscular atrophy, improving muscle function and nerve activity, show phase II study findings published in The Lancet.

Oncology

Osimertinib outplays chemotherapy in EGFR T790M-positive advanced NSCLC

lung_cancer

The third-generation tyrosine kinase inhibitor osimertinib significantly improves outcomes relative to platinum-based chemotherapy plus pemetrexed in advanced non-small-cell lung cancer patients who have acquired the epidermal growth factor receptor T790M mutation after initial treatment with an EGFR TKI, show the AURA3 results.

Headlines from across medwireNews

08-12-2016 | Cardiology | News | Article

Decision aid increases knowledge of ACS risk in patients with low-risk chest pain

Results of a randomized trial suggest that shared decision making facilitated by an aid increases knowledge of acute coronary syndrome risk and reduces hospital admissions compared with usual care among patients with low-risk chest pain in the emergency department.

08-12-2016 | Multiple sclerosis | News | Article

Newborn vitamin D status linked to future MS risk

Babies born with low levels of vitamin D may be at increased risk for multiple sclerosis in later life, suggests research.

07-12-2016 | Interventional cardiology | News | Article

Equivalent safety profiles of PCI, CABG in patients with unprotected left main coronary artery stenosis

Percutaneous coronary intervention and coronary artery bypass grafting have equivalent safety outcomes among patients with unprotected left main coronary artery stenosis, but there are higher rates of repeat revascularization with percutaneous coronary intervention, researchers report.

07-12-2016 | Interventional cardiology | News | Article

Lower bleeding risk with cangrelor versus clopidogrel–GPIs

Cangrelor is associated with a reduced risk for bleeding compared with clopidogrel plus routinely used glycoprotein IIb/IIIa inhibitors in patients undergoing percutaneous coronary intervention, results of a pooled analysis suggest.

07-12-2016 | Head and neck cancer | News | Article

Adjuvant chemotherapy ‘may be unnecessary’ for HPV-related OPSCC patients

US researchers question the addition of chemotherapy to the adjuvant treatment regimen in surgically managed patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma.

05-12-2016 | Alzheimer's disease | News | Article

Occupational therapy fails to slow functional decline in Alzheimer’s disease

The addition of 2 years of in-home occupational therapy to collaborative care does not provide functional benefits for patients with Alzheimer’s disease.

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medwireNews@ESMO2016

medwireNews brings you news and conference reports from the ESMO 2016 Congress, held in Copenhagen, Denmark.

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medwireNews@EAN2015

Highlights from the 1st conference of the European Academy of Neurology in Berlin, Germany.

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