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Neurology

Most patients with Down’s syndrome will have dementia at the time of death

Down's syndrome karyotype

Dementia is the proximate cause of death in 70% of older adults with Down’s syndrome, show findings from a large community-based study published in JAMA Neurology.

Oncology

RELAY: Ramucirumab–erlotinib a potential first-line option for EGFR-mutated NSCLC

Relay race

Combining erlotinib with ramucirumab significantly improves the progression-free survival of untreated patients with advanced EGFR mutation-positive non-small-cell lung cancer, suggest phase III results presented at the 2019 ASCO Annual Meeting in Chicago, Illinois, USA.

Ophthalmology

Intravitreal injection linked to substantial temporary blood pressure increase

Syringe

Patients undergoing intravitreal injections with anti–vascular endothelial growth factor agents can experience substantial transient increases in systolic blood pressure, Swiss researchers report.

Respiratory

Monocyte counts could predict IPF outcome

Monocyte

Elevated monocyte counts are associated with poor outcomes among patients with idiopathic pulmonary fibrosis, suggest study findings published in The Lancet Respiratory Medicine.

Rheumatology

European recommendations for the diagnosis of gout issued

Guidelines

EULAR has issued eight updated evidence-based recommendations to guide the diagnosis of gout.

Headlines from across medwireNews

18-06-2019 | Oncology | News | Article

Broadening clinical trial inclusion criteria doubles number of eligible NSCLC patients

Using expanded criteria for clinical trial inclusion could lead to nearly twice as many patients with advanced non-small-cell lung cancer being eligible for participation compared with traditional criteria, participants at the 2019 ASCO Annual Meeting in Chicago, Illinois, USA, heard.

18-06-2019 | Diabetes | News | Article

High-intensity exercise may trigger hypoglycemia counterregulatory response

Research presented at the 79th ADA Scientific Sessions in San Francisco, California, USA, suggests that high-intensity exercise can partially restore counterregulatory responses to hypoglycemia in people with impaired awareness of the condition.

18-06-2019 | Rheumatology | News | Article

Nintedanib reduces SSc-ILD progression across various subgroups

Nintedanib slows lung function decline in a variety of patients with systemic sclerosis-associated interstitial lung disease, suggests a subgroup analysis of data from the SENSCIS trial.

18-06-2019 | Diabetes | News | Article

Hyperglycemia may impact brain development in children with type 1 diabetes

Researchers report that having type 1 diabetes may affect children’s brain growth and cognitive development, with persistent hyperglycemia the most likely culprit.

17-06-2019 | Oncology | News | Article

Bevacizumab adds no value to chemotherapy for metastatic urothelial cancer

Adding bevacizumab to gemcitabine plus cisplatin chemotherapy does not improve overall survival when used as first-line therapy for metastatic urothelial carcinoma, show results of the phase III CALGB 90601 study.

17-06-2019 | Rheumatology | News | Article

Filgotinib beneficial for RA patients with no prior methotrexate exposure

Filgotinib, given in combination with methotrexate, may be a promising treatment option for methotrexate-naïve patients with moderate-to-severe rheumatoid arthritis, indicate findings from the FINCH 3 trial.

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