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Asthma

Sex, obesity, and immune disturbances inform severe asthma phenotype in later life

Bathroom scales_feet

With advancing age, asthma becomes more prevalent in women than men and is associated with obesity, greater airflow limitation, and lower markers of T-helper cell type 2 inflammation, study findings show.

HBV

Consensus reached on design of clinical trials for novel, curative HBV therapies

Discussion group

A panel of hepatitis B virus experts has issued a consensus statement intended to aid in standardizing the efficacy and safety appraisals of novel, potentially curative antiviral and immune modulatory agents.

Oncology

Post-HSCT maintenance rituximab improves mantle-cell lymphoma survival

IV drip_patient's hand

Maintenance treatment with the anti-CD20 antibody rituximab after induction immunochemotherapy and autologous hematopoietic stem-cell transplantation is associated with a significant survival benefit among young patients with mantle-cell lymphoma, phase III trial findings show.

Rheumatology

Romosozumab shows promise for fracture prevention in women with osteoporosis

Osteoporosis

Results of the phase III ARCH trial suggest that women with osteoporosis who are treated with romosozumab are less likely to experience fractures, but may have an increased risk for cardiovascular events, compared with those given alendronate.

Headlines from across medwireNews

17-10-2017 | Rheumatology | News | Article

Obesity associated with mobility loss in later life after surgery for OA

Study results suggest that maintaining a healthy bodyweight may reduce the risk for mobility limitation in later life among older women who undergo surgical joint replacement for osteoarthritis.

16-10-2017 | Rheumatology | News | Article

Support for continuing biologic treatment beyond 2 years following JIA remission

Children with oligoarticular or polyarticular juvenile idiopathic arthritis who stop biologic treatment within 2 years of achieving remission have an increased risk for relapse compared with those who continue treatment for a longer period, researchers report.

16-10-2017 | Oncology | News | Article

‘Surrogate’ retinoblastoma biopsy feasible using aqueous humor

Tumor-specific DNA can be retrieved from the aqueous humor of patients with retinoblastoma, say US researchers, allowing genetic analysis in patients who do not have a biopsy sample available.

13-10-2017 | Gastrointestinal cancer | News | Article

Deficient MMR phenotype linked to favorable FOLFOX colon cancer DFS

In patients with stage III colon cancer treated with adjuvant FOLFOX chemotherapy, DNA mismatch repair deficiency is associated with longer disease-free survival than MMR proficiency, confirms a pooled analysis published in JAMA Oncology.

12-10-2017 | Melanoma | News | Article

Oncolytic virus boosts ipilimumab response in advanced melanoma

Combining the oncolytic virus talimogene laherparepvec with the immune checkpoint inhibitor ipilimumab significantly improves treatment response compared with ipilimumab alone in patients with advanced melanoma, phase II study data show.

11-10-2017 | Rheumatology | News | Article

Further support for smoking cessation in RA patients

Smoking is associated with an increased risk for cardiovascular events and respiratory tract infections among patients with rheumatoid arthritis, and this risk decreases with each additional year of smoking cessation, researchers report.

Beyond the news

medwireNews@ESMO2016

medwireNews brings you news and conference reports from the ESMO 2016 Congress, held in Copenhagen, Denmark.

Click through to read the full reports of the latest research.

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medwireNews@EAN2015

Highlights from the 1st conference of the European Academy of Neurology in Berlin, Germany.

Click through to read research news from the conference.

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