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Asthma

Multivariate model predicts eosinophilic asthma without sputum induction

Blood sample

Researchers have designed a multivariate prediction model for identifying eosinophilic asthma that uses the activation state of peripheral blood eosinophils rather than sputum analysis.

HBV

HBV suppresses hepatic innate immune response

DNA background

The host hepatic innate immune response is downregulated in untreated patients with chronic hepatitis B virus infection, shows a gene expression analysis.

Oncology

Selumetinib adds no benefit to docetaxel in KRAS-mutant advanced NSCLC

lung_cancer2

Adding selumetinib to docetaxel does not improve progression-free survival over docetaxel alone in patients with previously treated, advanced, KRAS-mutant non-small-cell lung cancer, phase III trial data show.

Rheumatology

Intra-articular steroid injections not supported for knee OA

Old man_holding knee

Results of a randomized trial suggest no clinical benefits of triamcinolone injections for patients with symptomatic knee osteoarthritis.

Headlines from across medwireNews

25-05-2017 | Rheumatology | News | Article

Surgical interventions for OA may be cost-effective

News in brief

Total knee arthroplasty and total hip arthroplasty are cost-effective interventions for the treatment of osteoarthritis, results of a systematic review suggest.

25-05-2017 | Non-small-cell lung cancer | News | Article

Pembrolizumab receives agnostic approval for MSI-H/dMMR tumors

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24-05-2017 | Rheumatology | News | Article

Tocilizumab approved for giant cell arteritis

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24-05-2017 | Gynaecological cancer | News | Article

Bevacizumab benefits ovarian cancer patients irrespective of timing

Patients with platinum-resistant ovarian cancer gain significant survival benefit from treatment with bevacizumab, regardless of whether its given with or after chemotherapy, an exploratory analysis of AURELIA study data show.

23-05-2017 | Rheumatology | News | Article

Support for switching from infliximab to biosimilar CT-P13

Results of two independent studies suggest that patients with inflammatory arthritis can be switched from infliximab to the biosimilar CT-P13 without compromising the effectiveness of treatment.

23-05-2017 | Head and neck cancer | News | Article

Recommendation against routine thyroid cancer screening retained

In a statement published in JAMA, the US Preventive Services Task Force upholds its 1996 recommendation against screening for thyroid cancer among asymptomatic adults.

Beyond the news

medwireNews@ESMO2016

medwireNews brings you news and conference reports from the ESMO 2016 Congress, held in Copenhagen, Denmark.

Click through to read the full reports of the latest research.

Interested in paediatric endocrinology?

Visit our dedicated microsite for research news, interviews and in-depth analysis of paediatric endocrinology and growth disorders.

medwireNews@EAN2015

Highlights from the 1st conference of the European Academy of Neurology in Berlin, Germany.

Click through to read research news from the conference.

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