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Asthma

Airway type 2 inflammation refractory to corticosteroids in many severe asthma patients

Asthma attack_woman

Airway type 2 inflammation is not fully suppressed in around half of asthma patients despite receipt of inhaled corticosteroid treatment, study findings show.

HBV

ACP, CDC issue HBV vaccination, screening best practice advice

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The American College of Physicians and Centers for Disease Control and Prevention have released best practice guidance for hepatitis B virus vaccination, screening, and linkage to care.

Oncology

Neoadjuvant nivolumab could benefit patients with resectable NSCLC

Syringe_vials

Neoadjuvant treatment with the PD-1 inhibitor nivolumab shows promising activity in patients with untreated surgically resectable early non-small-cell lung cancer, with few side effects, US researchers report.

Rheumatology

Trial results back denosumab as a treatment option for glucocorticoid-induced osteoporosis

Osteoporosis

Patients with glucocorticoid-induced osteoporosis who are treated with denosumab have greater improvements in bone mineral density than those treated with risedronate, phase III trial results suggest.

Headlines from across medwireNews

20-04-2018 | Gastrointestinal cancer | News | Article

Short-acting calcium channel blockers may increase pancreatic cancer risk

Postmenopausal women who take short-acting calcium channel blockers could be at increased risk for developing pancreatic cancer, findings indicate.

20-04-2018 | Rheumatology | News | Article

JIA recommendations define treat-to-target strategy

An international taskforce has developed consensus recommendations for treating juvenile idiopathic arthritis to target.

19-04-2018 | Non-small-cell lung cancer | News | Article

First-line pembrolizumab plus chemotherapy boosts advanced NSCLC outcomes

Adding pembrolizumab to standard chemotherapy significantly delays disease progression and improves overall survival in patients with previously untreated metastatic nonsquamous non-small-cell lung cancer, KEYNOTE-189 data show.

19-04-2018 | Oncology | News | Article

Targeted inhibitor shows potential for RET-altered solid tumors

A selective inhibitor of the receptor tyrosine kinase RET could benefit patients with tumors harboring alterations in the oncogene, suggest early results presented at the American Association for Cancer Research Annual Meeting 2018.

19-04-2018 | Rheumatology | News | Article

‘Reassuring’ data on certolizumab pegol use during pregnancy

Treatment with the tumor necrosis factor inhibitor certolizumab pegol during pregnancy is not likely to be associated with teratogenic effects, researchers report.

18-04-2018 | Non-small-cell lung cancer | News | Article

Nivolumab plus ipilimumab benefits shown in highly mutated advanced NSCLC

CheckMate-227 shows that treatment with nivolumab plus ipilimumab significantly improves progression-free survival compared with chemotherapy in patients with advanced non-small-cell lung cancer and a high tumor mutational burden.

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