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Rheumatology

Trial results support management of cardiovascular risk factors in RA patients

Atherosclerosis

Managing traditional cardiovascular risk factors with a treat-to-target approach slows progression of subclinical atherosclerosis among patients with rheumatoid arthritis, suggest results from the FRANCIS trial.

Neurology

Most patients with Down’s syndrome will have dementia at the time of death

Down's syndrome karyotype

Dementia is the proximate cause of death in 70% of older adults with Down’s syndrome, show findings from a large community-based study published in JAMA Neurology.

Respiratory

Most patients with asthma will not experience an exacerbation

Asthma attack_woman

Only a third of patients with asthma will experience an exacerbation, show 7 years of observation in more than 50,000 adults with the condition.

Oncology

Concomitant TKI–PPI use may adversely affect cancer patient survival

Pills_various

Taking proton pump inhibitors alongside tyrosine kinase inhibitors is associated with an increased mortality risk in older cancer patients, research indicates.

Ophthalmology

Intravitreal injection linked to substantial temporary blood pressure increase

Syringe

Patients undergoing intravitreal injections with anti–vascular endothelial growth factor agents can experience substantial transient increases in systolic blood pressure, Swiss researchers report.

Headlines from across medwireNews

18-01-2019 | Kidney cancer | News | Article

Potential ‘risk of harm’ for older women with adjuvant sunitinib for RCC

Adjuvant treatment with sunitinib may be associated with an increased mortality risk for older female patients with renal cell carcinoma, suggests a post-hoc analysis of the ASSURE trial that compared sunitinib and sorafenib with placebo.

18-01-2019 | Non-small-cell lung cancer | News | Article

Prolonged OS possible for ALK-positive stage IV NSCLC

Individuals with stage IV non-small-cell lung cancer harboring anaplastic lymphoma kinase translocations can hope to achieve overall survival of nearly 7 years, suggests a US cohort analysis.

17-01-2019 | Oncology | News | Article

Mixed results for watch-and-wait strategy in rectal cancer

Although a watchful waiting approach to rectal cancer surgery is associated with a high rate of rectal preservation among patients who achieve a clinical complete response after neoadjuvant therapy, it may adversely affect survival and also distant control in certain patients, suggests data from a case series.

17-01-2019 | Rheumatology | News | Article

Real-world data support tocilizumab use in GCA patients

Tocilizumab treatment results in a “rapid and maintained” clinical improvement among patients with giant cell arteritis in routine clinical practice, researchers report.

17-01-2019 | Asthma | News | Article

Better adherence with once- than twice-daily ICS/LABA therapy in asthma patients

Patients with asthma who are treated with the once-daily inhaled corticosteroid/long-acting beta agonist regimen fluticasone furoate/vilanterol have better treatment adherence than those taking the twice-daily budesonide/formoterol combination, researchers report.

17-01-2019 | Multiple sclerosis | News | Article

Early aggressive treatment to delay conversion to secondary progressive MS

The findings from two studies published in JAMA show the benefits of initial disease-modifying therapy and nonmyeloablative haematopoietic stem cell transplantation in delaying conversion to secondary progressive multiple sclerosis.

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