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Neurology

Most patients with Down’s syndrome will have dementia at the time of death

Down's syndrome karyotype

Dementia is the proximate cause of death in 70% of older adults with Down’s syndrome, show findings from a large community-based study published in JAMA Neurology.

Oncology

Darolutamide reduces CRPC metastasis risk

Older man taking pill

Addition of the androgen receptor antagonist darolutamide to androgen deprivation therapy improves metastasis-free survival in patients with castration-resistant prostate cancer, indicate ARAMIS trial results.

Ophthalmology

Intravitreal injection linked to substantial temporary blood pressure increase

Syringe

Patients undergoing intravitreal injections with anti–vascular endothelial growth factor agents can experience substantial transient increases in systolic blood pressure, Swiss researchers report.

Respiratory

Lumacaftor–ivacaftor combination shows promise in young children with cystic fibrosis

Young child taking oral medicine

Trial findings published in The Lancet Respiratory Medicine support the use of combination therapy with lumacaftor and ivacaftor in children aged 2–5 years with cystic fibrosis homozygous for the F508del-CFTR mutation.

Rheumatology

Longevity of hip, knee replacements in OA patients estimated

Knee arthroplasty concept image (symbolic image with model)

Two meta-analyses published in The Lancet provide estimates for how long hip and knee replacements are likely to last in patients with osteoarthritis.

Headlines from across medwireNews

19-02-2019 | Diabetes | News | Article

Smartphone-based infrared camera accurately detects diabetic foot ulcers

A low-cost, smartphone-based infrared (IR) camera works as well as a high-end version for the detection of diabetic foot ulcers (DFU), study findings indicate.

19-02-2019 | Prostate cancer | News | Article

ARCHES shows enzalutamide benefit for mCSPC

Supplementing androgen deprivation therapy with enzalutamide delays radiologic progression in men with metastatic castration-sensitive prostate cancer, indicate phase III trial findings presented at the 2019 ASCO Genitourinary Cancers Symposium.

19-02-2019 | Kidney cancer | News | Article

Pembrolizumab–axitinib boosts untreated advanced RCC survival

Overall survival is significantly improved with the first-line combination of pembrolizumab and axitinib relative to sunitinib in patients with advanced renal cell carcinoma, shows the KEYNOTE-426 trial.

19-02-2019 | Rheumatology | News | Article

Durable efficacy of tofacitinib in RA patients demonstrated

Patients with rheumatoid arthritis who are treated with the Janus kinase inhibitor tofacitinib alongside methotrexate experience sustained efficacy for up to 2 years, suggest follow-up results from the phase III ORAL Scan study.

19-02-2019 | Diabetes | News | Article

Data highlight opportunities to diagnose type 1 diabetes before DKA onset

Children with type 1 diabetes are more likely than their non-diabetic peers to seek primary care for a number of specific conditions in the year before their diagnosis, which could aid detection before the onset of diabetic ketoacidosis, say researchers.

18-02-2019 | Rheumatology | News | Article

No benefit of prolonged abatacept cessation before joint replacement in RA patients

Among patients with rheumatoid arthritis undergoing elective joint replacement, stopping intravenous abatacept treatment for more than one dosing interval prior to surgery may not result in better postoperative outcomes than a shorter length of discontinuation, researchers report.

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