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Asthma

Sex, obesity, and immune disturbances inform severe asthma phenotype in later life

Bathroom scales_feet

With advancing age, asthma becomes more prevalent in women than men and is associated with obesity, greater airflow limitation, and lower markers of T-helper cell type 2 inflammation, study findings show.

HBV

Consensus reached on design of clinical trials for novel, curative HBV therapies

Discussion group

A panel of hepatitis B virus experts has issued a consensus statement intended to aid in standardizing the efficacy and safety appraisals of novel, potentially curative antiviral and immune modulatory agents.

Oncology

Post-HSCT maintenance rituximab improves mantle-cell lymphoma survival

IV drip_patient's hand

Maintenance treatment with the anti-CD20 antibody rituximab after induction immunochemotherapy and autologous hematopoietic stem-cell transplantation is associated with a significant survival benefit among young patients with mantle-cell lymphoma, phase III trial findings show.

Rheumatology

Romosozumab shows promise for fracture prevention in women with osteoporosis

Osteoporosis

Results of the phase III ARCH trial suggest that women with osteoporosis who are treated with romosozumab are less likely to experience fractures, but may have an increased risk for cardiovascular events, compared with those given alendronate.

Headlines from across medwireNews

18-10-2017 | Rheumatology | News | Article

Methotrexate tapering ‘an appropriate strategy’ in RA patients

Results of a randomized trial suggest that methotrexate can be tapered in patients with rheumatoid arthritis receiving tocilizumab treatment without compromising disease control.

18-10-2017 | Prostate cancer | News | Article

HSD3B1 variant may predict treatment response in advanced prostate cancer

The HSD3B1 1245C variant allele could be used as a biomarker to predict treatment response in different groups of men with advanced prostate cancer, show two studies published in JAMA Oncology.

17-10-2017 | Oncology | News | Article

No survival, QoL gain for many EMA cancer drug approvals

Research published in The BMJ shows that around half of the anticancer drugs recently approved by the European Medicines Agency come with no clear evidence of an overall survival or quality of life benefit.

17-10-2017 | Rheumatology | News | Article

Obesity associated with mobility loss in later life after surgery for OA

Study results suggest that maintaining a healthy bodyweight may reduce the risk for mobility limitation in later life among older women who undergo surgical joint replacement for osteoarthritis.

16-10-2017 | Rheumatology | News | Article

Support for continuing biologic treatment beyond 2 years following JIA remission

Children with oligoarticular or polyarticular juvenile idiopathic arthritis who stop biologic treatment within 2 years of achieving remission have an increased risk for relapse compared with those who continue treatment for a longer period, researchers report.

16-10-2017 | Oncology | News | Article

‘Surrogate’ retinoblastoma biopsy feasible using aqueous humor

Tumor-specific DNA can be retrieved from the aqueous humor of patients with retinoblastoma, say US researchers, allowing genetic analysis in patients who do not have a biopsy sample available.

Beyond the news

medwireNews@ESMO2016

medwireNews brings you news and conference reports from the ESMO 2016 Congress, held in Copenhagen, Denmark.

Click through to read the full reports of the latest research.

Interested in paediatric endocrinology?

Visit our dedicated microsite for research news, interviews and in-depth analysis of paediatric endocrinology and growth disorders.

medwireNews@EAN2015

Highlights from the 1st conference of the European Academy of Neurology in Berlin, Germany.

Click through to read research news from the conference.

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