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Rheumatology

Tocilizumab not linked to elevated cardiovascular risk in RA patients

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Patients with rheumatoid arthritis who are treated with tocilizumab have a similar cardiovascular risk profile to those taking most other biological DMARDs, results of a real-world study suggest.

Respiratory

Proportion of asthma patients who could benefit from anti-IL-5 treatment estimated

Antibodies

Researchers estimate that 2% of patients with adult-onset eosinophilic asthma could benefit from treatment involving antibodies against the interleukin-5 pathway.

HBV

Global HBV prevalence estimated at 3.9%

World map

More than 290 million people, or 3.9% of the global population, are infected with hepatitis B virus, and while efforts to combat infection are improving, greater access to diagnosis and treatment is needed to meet global targets, report The Polaris Observatory Collaborators.

Neurology

Ibudilast slows brain shrinkage in progressive multiple sclerosis patients

MRI brain scan

Ibudilast may slow brain atrophy in patients with progressive multiple sclerosis, show findings from a phase II study.

Oncology

Meta-analysis consolidates evidence against PSA-based screening

PSA test

Prostate-specific antigen-based screening may lead to a modest reduction in prostate cancer-specific mortality but has no effect on overall survival, say the authors of a meta-analysis published in The BMJ.

Headlines from across medwireNews

19-09-2018 | Oncology | News | Article

Persistent mutations post-transplant predict MDS disease progression

Persistent disease-associated mutations detected in the bone marrow 30 days after stem cell transplantation are associated with an increased risk for disease progression among patients with myelodysplastic syndrome, research shows.

19-09-2018 | Rheumatology | News | Article

Extended-release triamcinolone acetonide viable for osteoarthritis patients with type 2 diabetes

Triamcinolone acetonide extended-release may be a good option for the treatment of knee osteoarthritis in patients with comorbid type 2 diabetes, suggest phase II study findings.

18-09-2018 | Oncology | News | Article

Allogeneic HSCT-treated patients often receive medically intense end-of-life care

A US research team has found that end-of-life care among individuals who undergo allogeneic hematopoietic stem cell transplantation can often be medically intense.

18-09-2018 | Oncology | Main feed | News

Durvalumab, abemaciclib approvals announced by EMA

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17-09-2018 | Non-small-cell lung cancer | News | Article

FLAURA findings add to evidence for CNS efficacy of osimertinib in advanced NSCLC

Osimertinib treatment is associated with a reduced risk for central nervous system progression relative to erlotinib or gefitinib in patients with epidermal growth factor receptor-mutated, advanced non-small-cell lung cancer and brain metastases, trial results suggest.

14-09-2018 | Rheumatology | News | Article

Early RA disease activity lower with methotrexate combination than methotrexate alone

Methotrexate–hydroxychloroquine combination therapy is associated with lower disease activity than methotrexate alone in early rheumatoid arthritis, according to a head-to-head comparison published in Rheumatology.

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