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Neurology

Most patients with Down’s syndrome will have dementia at the time of death

Down's syndrome karyotype

Dementia is the proximate cause of death in 70% of older adults with Down’s syndrome, show findings from a large community-based study published in JAMA Neurology.

Oncology

Immune checkpoint inhibitors viable in advanced cancer complicated by HIV

Virus cells_3D

Immune checkpoint inhibitor therapy is well tolerated by patients with HIV infection and advanced-stage cancer and does not appear to adversely affect HIV viral load or CD4 cell count, suggest results of a systematic data review.

Ophthalmology

Intravitreal injection linked to substantial temporary blood pressure increase

Syringe

Patients undergoing intravitreal injections with anti–vascular endothelial growth factor agents can experience substantial transient increases in systolic blood pressure, Swiss researchers report.

Respiratory

Lumacaftor–ivacaftor combination shows promise in young children with cystic fibrosis

Young child taking oral medicine

Trial findings published in The Lancet Respiratory Medicine support the use of combination therapy with lumacaftor and ivacaftor in children aged 2–5 years with cystic fibrosis homozygous for the F508del-CFTR mutation.

Rheumatology

Ibuprofen may be a ‘reasonable option’ for analgesia after hip replacement

Hip replacement

Patients who are treated with ibuprofen alone experience comparable pain control in the first day after hip replacement to those give acetaminophen plus ibuprofen, findings from the PANSAID trial suggest.

Headlines from across medwireNews

15-02-2019 | Diabetes | News | Article

Gap between glycemic, patient-reported outcomes in HypoDE study

Continuous glucose monitoring has a less impressive effect on patient-reported outcomes than on glycemic control among patients with type 1 diabetes, reveal the HypoDE investigators.

15-02-2019 | Prostate cancer | News | Article

Further support for [177Lu]-PSMA-617 in men with mCRPC

Results from an expansion cohort add support for the use of lutetium-177-prostate-specific membrane antigen-617 in heavily pretreated men with metastatic castration-resistant prostate cancer.

15-02-2019 | Prostate cancer | News | Article

Real-world data confirm better mCRPC OS with hormonal therapy in Black versus White men

An analysis of a US database shows that Black individuals who receive abiraterone acetate or enzalutamide for metastatic castration-resistant prostate cancer have better overall survival than their White counterparts.

15-02-2019 | Rheumatology | News | Article

Longevity of hip, knee replacements in OA patients estimated

Two meta-analyses published in The Lancet provide estimates for how long hip and knee replacements are likely to last in patients with osteoarthritis.

14-02-2019 | Prostate cancer | News | Article

Long-term data support SBRT for low-, intermediate-risk prostate cancer

Stereotactic body radiotherapy has a favorable long-term disease control and safety profile in the setting of low- or intermediate-risk prostate cancer, say US researchers who analyzed individual patient data from over 2000 prospectively treated men.

14-02-2019 | Diabetes | News | Article

Artificial pancreas use viewed positively by users and caregivers

Daytime use of a day-and-night hybrid artificial pancreas system has a positive impact on the lives of users and their caregivers, show results of a longitudinal qualitative study.

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