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Oncology

Abiraterone best given before, not after, enzalutamide in mCRPC

Patient taking tablets

A sequencing strategy that uses abiraterone acetate plus prednisone followed by enzalutamide, rather than the opposite, provides the greatest clinical benefit to patients with newly diagnosed metastatic castration-resistant prostate cancer, researchers report.

Respiratory

Monocyte counts could predict IPF outcome

Monocyte

Elevated monocyte counts are associated with poor outcomes among patients with idiopathic pulmonary fibrosis, suggest study findings published in The Lancet Respiratory Medicine.

Rheumatology

Guselkumab shows promise for PsA

Antibodies (illustration)

Findings from the DISCOVER-1 and DISCOVER-2 trials suggest that the interleukin-23 inhibitor guselkumab may be a promising treatment option for people with psoriatic arthritis.

Headlines from across medwireNews

22-11-2019 | Diabetes | News | Article

Add-on liraglutide benefits overweight insulin pump users with poor glycemic control

Adding liraglutide to continuous subcutaneous insulin infusion significantly reduces glycated hemoglobin without increasing hypoglycemia in overweight and obese people with type 1 diabetes and suboptimal glycemic control, Danish research shows.

21-11-2019 | Rheumatology | News | Article

axSpA management needs to look beyond disease activity and function

To improve the quality of life of patients with ankylosing spondylitis, research suggests that fatigue, poor sleep, and mental health need to be addressed in addition to managing disease activity and function.

21-11-2019 | Rheumatology | News | Article

RA comorbidities signal a need to screen

US researchers have identified a number of chronic conditions associated with rheumatoid arthritis, including some that may predispose to RA development and others that may arise as a result of RA.

21-11-2019 | Oncology | News | Article

Data support immunotherapy combination for RCC with variant histology, sarcomatoid features

A meaningful proportion of patients with advanced renal cell carcinoma with variant histology or sarcomatoid differentiation respond to the immunotherapy combination of atezolizumab and bevacizumab without experiencing severe toxicity, phase II study data show.

21-11-2019 | Diabetes | News | Article

Glycated hemoglobin variability between clinic visits linked to adverse events

Frequent fluctuations in glycated hemoglobin levels between clinic visits are associated with death, cardiovascular disease, and microvascular complications in patients newly diagnosed with type 2 diabetes, a Scottish study suggests.

20-11-2019 | Rheumatology | News | Article

Insufficient diversity in RA clinical trial populations

A systematic review has identified insufficient representation of people from racial minority groups, older individuals, and men in randomized controlled trials investigating treatments for rheumatoid arthritis.

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