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Asthma

Eosinophilia linked to lung function decline irrespective of asthma symptoms

Blood sample

High blood eosinophil counts are associated with airflow obstruction and lung function decline in patients with asthma, but also in people without respiratory symptoms, population-based study findings show.

HBV

Updated AASLD guidance released on HBV prevention, diagnosis, and treatment

Folder_Binders in background

The American Association for the Study of Liver Diseases has issued a guidance statement for chronic hepatitis B virus, covering topics ranging from screening and prevention through to the clinical management of patients.

Oncology

Further data support aBSI as a prognostic marker in mCRPC

Bone scintigraphy scan

Prospective data confirm use of the automated Bone Scan Index as an independent prognostic marker of survival and other clinical outcomes in men with metastatic castration-resistant prostate cancer, researchers report.

Rheumatology

Diclofenac linked to increased myocardial infarction risk in SpA patients

Heartbeat

Current use of the nonsteroidal anti-inflammatory drug diclofenac, but not of naproxen, is associated with a threefold increased risk for myocardial infarction among individuals with spondyloarthritis, according to recent findings.

Headlines from across medwireNews

25-05-2018 | Colorectal cancer | News | Article

Worse prognosis for patients with V600E BRAF-mutated colorectal liver metastases

The presence of the BRAF V600E mutation in colorectal liver metastases is associated with a worse prognosis and increased risk for recurrence, according to findings from an international retrospective cohort study.

25-05-2018 | Rheumatology | News | Article

Comorbid fibromyalgia common in patients with inflammatory arthritis

Results of a systematic review and meta-analysis suggest that a substantial proportion of patients with chronic inflammatory arthritis have concomitant fibromyalgia, which may influence measures of disease activity.

24-05-2018 | Oncology | News | Article

Tremelimumab plus durvalumab active in unresectable mesothelioma

Preliminary results suggest a role for the combination of the CTLA-4 inhibitor tremelimumab and the PD-L1 blocker durvalumab in the treatment of inoperable pleural or peritoneal mesothelioma.

24-05-2018 | Rheumatology | News | Article

Disease activity, lifestyle factors may predict methotrexate response in RA patients

A predictive model including baseline disease activity score, smoking status, and alcohol consumption may help to identify which patients with rheumatoid arthritis are likely to have a poor response to methotrexate-based treatment, researchers report.

23-05-2018 | Prostate cancer | News | Article

[177Lu]-PSMA-617 shows promise for heavily pretreated mCRPC

Radionuclide treatment with lutetium-177-prostate-specific membrane antigen-617 shows potential for men with metastatic castration-resistant prostate cancer that has progressed after standard therapy, researchers report.

23-05-2018 | Rheumatology | News | Article

Online self-management program disappoints in SSc trial

Results of a randomized controlled trial suggest that an internet-based self-management program is no more beneficial than an educational book for patients with systemic sclerosis.

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