Parkinson’s motor symptoms linked to overactive bladder
medwireNews: Japanese research shows that men with Parkinson's disease are significantly more likely to experience symptoms of overactive bladder if they have finger taps or constipation.
The authors, Akira Tsujimura (Osaka University) and colleagues, who report their findings in a study of 161 men say: "Although a study on a larger scale is required to further assess the association of information on finger taps, as well as severity of Parkinson's disease symptoms with overactive bladder symptom score [OABSS], information on finger taps and severity of constipation should be obtained when assessing urological patients with Parkinson's disease."
Overall, 77 (47.8%) men had overactive bladder according to the OABSS. Patients were classified according to the Unified Parkinson's Disease Rating Scale motor section part III as experiencing mild (1-2 points) or severe (>2 points) motor symptoms (tremor at rest, finger taps, rigidity, arising from chair, gait, posture, and postural stability). Non-motor symptoms (erectile dysfunction, constipation, syncope/blackout) were recorded as absent or present.
OABSS scores were significantly higher in patients with severe versus mild symptoms of finger taps (mean 7.6 vs 5.2) and gait (6.7 vs 5.3), and OABSS scores were also significantly higher in patients with erectile dysfunction (6.7 vs 5.1) and constipation (6.3 vs 4.6) than in patients without.
However, in multivariate analysis, only finger taps and constipation were independently associated with OABSS, the authors report in the International Journal of Urology.
While lower urinary tract symptoms are common in patients with Parkinson's disease, Tsujimara and colleagues say that the association between motor symptoms and overactive bladder has not previously been reported.
"The mechanism behind the close relationship between finger taps and [overactive bladder] symptoms is not obvious," they remark. However, finger tapping has been linked to responses in the striatum, and detrusor hyperreflexia may also be a result of ineffective dopamine receptor activation, the authors note.
"A larger-scale study will be necessary to assess symptoms of PD [Parkinson's disease] associated with [overactive bladder] symptoms because of the variability in the degree of symptoms of PD," they conclude.
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By Kirsty Oswald, medwireNews Reporter