Beta blockers tied to improved TNBC survival

Xray image of breast cancer

Author: Shreeya Nanda medwireNews: Among women with triple-negative breast cancer (TNBC), the use of beta blockers may improve BC-specific survival, suggests a population-based cohort study and meta-analysis. “The biological reason behind the association between β-blocker use and improved prognosis for TNBC patients but not for other BC patients remains unclear,” say the study authors in […]

Neutrophil to lymphocyte ratio may help identify ICI candidates in NSCLC

leukocyte attacking a cancer cell

Author: Laura Cowen medwireNews: A low baseline neutrophil to lymphocyte ratio (NLR) may identify patients with non-small-cell lung cancer (NSCLC) who are more likely to derive survival benefit from atezolizumab than from docetaxel, study findings indicate. Writing in Cancer, Alessio Cortellini (Imperial College London, UK) and co-authors say: “The NLR proved to be an effective tool […]

Predictors of complete remission in SLE identified

man suffers from systemic lupus erythematosus

Author: Hannah Kitt medwireNews: Research has revealed factors associated with complete remission in patients with systemic lupus erythematosus (SLE), including lack of renal involvement and antiphospholipid syndrome, White ethnicity, and older age at diagnosis. The investigators also found that people who did not achieve any sustained remission had a higher risk for early mortality than those […]

Diabetes hastens progression of preclinical heart failure

Clutching chest due to heart attack

Author: Eleanor McDermid medwireNews: The presence of diabetes in people with preclinical heart failure (HF) shortens the time to a first clinical event, especially if blood glucose is poorly controlled, show data from the ARIC study. “Our results suggest that targeting diabetes early in the HF process is critical,” write Justin Echouffo-Tcheugui (Johns Hopkins University, […]

Targeted therapy not linked to serious infection risk in older people with RA

woman with hand pain_rheumatoid arthritis

Author: Laura Cowen medwireNews: Older people with rheumatoid arthritis (RA) are not at increased risk for hospitalization with infection when receiving targeted therapy with biologics or Janus kinase (JAK) inhibitors rather than methotrexate, Japanese researchers report. Masayoshi Harigai (Tokyo Women’s Medical University School of Medicine) and colleagues used Japanese insurance claims data to identify 22,696 individuals […]

JAVELIN Bladder 100 exploratory analyses point to wide use of maintenance avelumab

Illustration of bladder cancer

Author: Shreeya Nanda medwireNews: Maintenance treatment with avelumab improves the long-term outcomes of advanced urothelial cancer patients regardless of their response to first-line chemotherapy and receipt of second-line therapy, suggest exploratory analyses of the JAVELIN Bladder 100 trial. The findings were presented in posters at the 2022 ASCO Annual Meeting in Chicago, Illinois, USA, and […]

Researchers calculate unannounced snack threshold for closed-loop system

Young diabetic patient with insulin pump

Author: Laura Cowen medwireNews: Children and adolescents using an advanced hybrid closed-loop system (a-HCL) for type 1 diabetes can tolerate an unannounced snack containing 20 g of carbohydrate without excessive blood sugar fluctuations, Italian researchers report. Daniela Nisticò (University of Trieste) and colleagues say their findings “may be particularly helpful for children who are still not […]

DMARD treatment has ‘profound anticoagulant effects’ in early RA

Activated platelets in red blood cells

Author: Claire Barnard medwireNews: Analysis of data from the NORD-STAR study suggests that people with early rheumatoid arthritis (RA) have increased levels of coagulation biomarkers, putting them at increased risk for venous thromboembolism, and initial treatment with DMARDs can help reduce this imbalance. Bas Dijkshoorn (Amsterdam Rheumatology and Immunology Center, the Netherlands) and colleagues analyzed […]