High overall response rates to COVID-19 vaccination in people taking JAK inhibitors
medwireNews: The majority of patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA) on Janus kinase (JAK) inhibitor therapy produce an antibody response to vaccines against SARS-CoV-2, researchers report.
Raphaèle Seror (Université Paris-Saclay, France) and colleagues found that 88% of 113 participants from the French MAJIK-SFR Registry had detectable antibodies against the SARS-CoV-2 spike protein in March–July 2021, an average of 8.7 weeks after full vaccination. Most patients in the cohort were women (72%) with a diagnosis of RA (87%); the most commonly used JAK inhibitor was baricitinib (50%), followed by tofacitinib (27%) and upadacitinib (24%).
The study authors say that people treated with upadacitinib were less likely to generate an antibody response than those on baricitinib or tofacitinib, with response rates of 74% versus 91% and 97%, respectively. All of the nonresponders on baricitinib (n=5) or tofacitinib (n=1) were aged 65 years or older, whereas four of the seven nonresponders on upadacitinib were younger than 65 years.
“These results need to be confirmed in a prospective trial but suggest that in patients aged 65 years and older or treated with upadacitinib, or both, serological assessment might be recommended to guide clinical decision in non-responders,” write Seror et al in a comment published in The Lancet Rheumatology.
They note that “[n]o other parameters, including concomitant use of methotrexate, corticosteroids, dose of JAK inhibitor, disease activity, or type of vaccine were associated with non-response.”
medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2021 Springer Healthcare Ltd, part of the Springer Nature Group
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