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27-10-2021 | Rheumatology | News | Article

approvalsWatch

FDA approves avacopan for ANCA-associated vasculitis

Author: Claire Barnard

medwireNews: The US FDA has approved avacopan, an orally-administered inhibitor of the complement 5a (C5a) receptor, as an add-on treatment option for severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

Avacopan is recommended for the treatment of two types of ANCA-associated vasculitis – granulomatosis with polyangiitis and microscopic polyangiitis – at a dose of 30 mg twice daily, given in combination with standard therapy including glucocorticoids. The FDA notes that avacopan “does not eliminate glucocorticoid use.”

The efficacy of avacopan for ANCA-associated vasculitis was shown in the phase 3 ADVOCATE trial, which compared remission rates with the C5a receptor inhibitor versus placebo when added to standard treatment with rituximab or cyclophosphamide followed by azathioprine.

medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2021 Springer Healthcare Ltd, part of the Springer Nature Group

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