ESR, disease activity associated with uveitis onset in JIA patients
medwireNews: Study results suggest that laboratory biomarkers and disease activity scores could help to identify patients with juvenile idiopathic arthritis (JIA) who have a high risk for uveitis.
In a multivariable analysis of data from 954 patients, 14% of whom developed uveitis over a mean follow-up of 3.7 years, Christoph Tappeiner (Bern University Hospital, Switzerland) and colleagues found that patients with elevated erythrocyte sedimentation rates (ESR; ≥20 mm/h) and S100A12 levels (≥250 ng/mL) at baseline had a significantly elevated risk for uveitis onset, with hazard ratios (HRs) of 2.36 and 2.10, respectively.
Elevated ESR during follow-up was also a significant predictor of uveitis (HR=2.44), as was having moderate or high disease activity, defined as clinical Juvenile Arthritis Disease Activity Score above 1.5 points for oligoarticular JIA, and above 2.5 points for polyarticular JIA (HR=4.30).
In line with previous studies, the team also found that patients with antinuclear antibodies and those with JIA onset at an age of younger than 3 years had a significantly elevated risk for developing uveitis.
These findings “confirmed demographic risk factors” for uveitis, and suggest that disease activity scores and laboratory biomarkers “are promising tools to better define the group of JIA patients at high risk for uveitis onset,” conclude Tappeiner et al in Arthritis & Rheumatology.
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