Skip to main content

14-06-2010 | Respiratory | Article

Uncontrolled asthma increases risk for activity limitations


Free abstract

MedWire News: Patients with uncontrolled asthma are at greater risk for activity limitations than those with controlled asthma, research shows.

Writing in the Annals of Allergy, Asthma and Immunology, Tmirah Haselkorn (Genentech Inc, South San Francisco, California, USA) and team explain that “uncontrolled asthma remains prevalent in the USA and confers a substantial burden on the health care system.”

To investigate the association between uncontrolled asthma and activity limitations, and the extent to which comorbidities play a role, the researchers studied data on a nationally representative sample of 1812 individuals with moderate to severe asthma who participated in the Real-world Evaluation of Asthma Control and Treatment (REACT) study.

All the participants completed questionnaires on activity limitations in four categories: outdoor activity, physical activity, daily activity, and environmental triggers.

Results from the Asthma Control Test showed that 809 patients had controlled and 1003 had uncontrolled disease.

Analysis revealed that patients with uncontrolled asthma were significantly more likely to have outdoor, physical, and daily activity limitations than those with controlled disease, at odds ratios of 2.58, 2.62, and 1.66, respectively.

A number of cormorbid conditions, including arthritis, gastro-esophageal reflux disease, hypercholesterolemia, and depression, were associated with activity limitation. However, the link between uncontrolled asthma and activity limitation remained after accounting for such conditions and patient demographics.

Haselkorn and team conclude: “Compared with patients with controlled asthma, those with uncontrolled asthma are at higher risk for limitations in outdoor activity, physical activity, and daily activity.”

They add: “To help patients achieve optimal health, asthma management should include routine assessment of activity limitations and assessment and coordinated care for comorbid conditions.”

MedWire ( is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010

By Mark Cowen

Related topics