Nasal polyps reflect tissue remodeling mediator changes in rhinosinusitis
MedWire News: Mediators of tissue remodeling differ between chronic rhinosinusitis (CRS) patients with and without nasal polyps, researchers have found.
“CRS is characterized by persistent inflammation of the nasal and paranasal mucosa and is currently classified into two subgroups on the basis of the absence or presence of nasal polyps, with distinctive inflammatory cell and mediator profiles,” explain Ping Lin (Sichuan University, Chengdu, China) and team.
They add: “Evidence suggests that there may also be differences between the two subtypes with regard to certain features of remodeling, such as basement membrane thickening, squamous metaplasia, collagen deposition, and goblet cell and glandular hyperplasia.”
In the current study, the researchers assessed expression of mediators associated with tissue remodeling in 12 chronic rhinosinusitis patients with nasal polyps (CRSwNP), 12 chronic rhinosinusitis patients without nasal polyps (CRSsNP), and 12 controls who were aged 17–60 years.
Nasal tissue samples were collected from the participants and analyzed for expression of transforming growth factor (TGF)-β1, matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), collagen, and regulatory T cells.
The researchers found that patients with CRSwNP and controls had significantly lower concentrations of TGF-β1, TIMP-1, TIMP-4, forkhead box P3 (FOXP3), and collagen than those with CRSsNP.
Concentrations of MMP-7 and MMP-9 were similar between CRSwNP and CRSsNP patients, but significantly higher in both these groups than in controls, while there were no significant differences among any of the groups regarding MMP-2 and TIMP-2 concentrations.
“Our study has demonstrated that there are significant differences in the synthesis/expression of TGF-β1, MMPs, TIMPs, FOXP3, and collagen in adult Chinese patients with CRSwNP and CRSsNP,” Lin and team conclude.
“Furthermore, these data suggest that the differences in these mediators are predominantly integral to the development of nasal polyps, and thus appropriate manipulation of these mediators may lead to better treatment of patients with nasal polyps.”
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By Mark Cowen