Sleep apnea may increase risk for psoriasis
MedWire News: Patients with obstructive sleep apnea (OSA) have an increased risk for psoriasis compared with the general population, suggest study results.
"Increasing evidence has shown that patients with OSA have a higher risk of various comorbid medical diseases, such as cardiovascular diseases, stroke, insulin resistance, and Type 2 diabetes mellitus," write Herng-Ching Lin (Taipei Medical University, Taiwan) and colleagues in Sleep Medicine.
"Although mechanisms underlying the link between OSA and these medical comorbidities remains to be elucidated, sympathetic overactivity, hypercoagulability, and activation of inflammatory pathways had been proposed as possible factors contributing to the associations," they add.
To investigate potential links between OSA and psoriasis, Lin and team analyzed data from the Taiwan Longitudinal Health Insurance Database 2000.
In total, 2258 OSA patients and 11,255 age-, and gender-matched individuals without the sleep disorder who made an ambulatory care visit between 2001 and 2005 were included in the analysis.
All of the participants were followed up for 3 years from the index ambulatory care visit for the development of psoriasis.
Lin and co-workers report that 36 (0.27%) participants developed psoriasis during the follow-up period. Of these, 11 patients had OSA and 25 did not have the sleep disorder, representing 0.49% and 0.22% of these patient groups, respectively.
After accounting for monthly income, geographic location, obesity, and urbanization level, the team calculated that patients with OSA were a significant 2.30-fold more likely to develop psoriasis over the follow-up period than those without OSA.
"Our results suggest that OSA is associated with an increased risk of subsequent psoriasis," say Lin et al.
"Future studies that include the severity index of OSA, health risk behaviors, and body mass index are needed to clarify the association between sleep-disordered breathing and psoriasis," they conclude.
By MedWire Reporters