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06-02-2012 | Article

PPI use may risk hip fracture


BMJ 2012; 344: e372

Chronic use of proton-pump inhibitors (PPIs) increases the risk of hip fractures among postmenopausal women, a study suggests.

US researchers found that women who regularly used PPIs for at least 2 years had a 35% increased relative risk of hip fracture.

This increase in risk was seen after accounting for age, body mass index, physical activity and calcium intake, as well as the reason for taking a PPI.

The study, by Professor Andrew Chan (Harvard Medical School, Boston, Massachusetts) and colleagues, included nearly 80,000 women enrolled in the Nurses' Health Study, who provided data on use of PPIs and other risk factors every 2 years from 2000 to 2008.

They report that the increase in hip fractures was even more pronounced among smokers (both current and former), who had over a 50% increased risk compared with smokers who did not use PPIs.

The risk was also greater the longer women had used PPIs for - the overall increase in risk rose to 40% with 4 years' use and 50% with 6-8 years' use of the drugs.

Reporting their findings in the BMJ, the authors note that the US Food and Drug Administration recently revised labeling on PPIs to warn of their link to fractures.

"Our data suggest the importance of carefully evaluating the need for long term, continuous use of PPIs, particularly among individuals with a history of smoking," they conclude.

GP News is an independent clinical news service provided by Springer Healthcare Limited. © Springer Healthcare Ltd; 2012

By Caroline Price