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Pediatrics

Pediatrics

24-06-2022 | Diabetes | News | Article

Type 1 diabetes increases MI case–fatality risk

Results from a nationwide registry study show that having type 1 diabetes places people at a significantly increased risk for dying within a year after having a myocardial infarction.

24-06-2022 | Oncology | News | Article

Focal ultrasound may offer intermediate-risk prostate cancer alternative to radiation, surgery

Magnetic resonance imaging-guided focal ultrasound therapy is a feasible treatment for grade group 2–3 prostate cancer, indicate phase 2b trial findings published in The Lancet Oncology.

24-06-2022 | Rheumatology | News | Article

Counseling intervention boosts breastfeeding rates among women with RA

Women with active rheumatoid arthritis who receive pregnancy counseling are as likely to breastfeed their children as women in the general population, indicate findings from the Preconceptional Counselling in Active Rheumatoid Arthritis study.

23-06-2022 | Rheumatology | News | Article

TNF inhibitor tapered T2T strategy feasible in PsA and axSpA

A tapering treat-to-target strategy can lead to a large reduction in TNF inhibitor dose without impacting disease control in people with psoriatic arthritis or axial spondyloarthritis, study findings indicate.

23-06-2022 | Oncology | News | Article

Tumor mutational burden ‘valuable biomarker’ for ICI response in NSCLC

High tumor mutational burden is associated with a better response to immune checkpoint inhibitors in people with non-small-cell lung cancer across all levels of PD-L1 expression, US researchers report.

23-06-2022 | Diabetes | News | Article

Low risk from reversing diabetes overtreatment in nursing home residents

Deintensifying diabetes treatment does not increase the risk for short-term adverse outcomes in male nursing home residents with limited life expectancy or advanced dementia, say researchers.

23-06-2022 | Oncology | News | Article

Nordic childhood ALL review shows ‘fewer’ but ‘harder-to-cure’ relapses

The risk of relapse after treatment for childhood acute lymphoblastic leukaemia has decreased in the past 3 decades but the likelihood of successful treatment of relapse has not improved, suggests a review of three Nordic Society of Pediatric Hematology and Oncology clinical trials.

This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.

22-06-2022 | Diabetes | News | Article

SGLT1/2 inhibitor shows early promise in NASH

The SGLT1/2 inhibitor licogliflozin has reduced liver enzyme levels in people with nonalcoholic steatohepatitis in a phase 2 trial published in Nature Medicine.

21-06-2022 | Oncology | News | Article

USPSTF continues to recommend against supplement use to prevent cancer, CVD in latest update

The USPSTF continues to recommend against the use of beta carotene and vitamin E for the primary prevention of cancer or cardiovascular disease in its updated 2022 recommendations, and maintains that the evidence is insufficient to assess the benefit–risk balance for the use of single- or paired-nutrient and multivitamin supplements.

21-06-2022 | Diabetes | News | Article

Real-world data confirm SGLT2 inhibitor renoprotection in type 2 diabetes

People with type 2 diabetes have a lower risk for chronic kidney disease progression and death when using SGLT2 inhibitors than when given DPP-4 inhibitors, real-world study data show.

21-06-2022 | Rheumatology | News | Article

Low-dose glucocorticoids show no negative impact on BMD

Low glucocorticoid doses are not associated with reduced bone mineral density in people with inflammatory rheumatic and musculoskeletal diseases, observational study findings indicate.

20-06-2022 | Diabetes | News | Article

Hypoglycemia, rebound hyperglycemia disturbs LV function in type 1 diabetes

A randomized crossover trial shows that both hypoglycemia and rebound hyperglycemia trigger persistent increases in left ventricular function in people with type 1 diabetes.

20-06-2022 | Oncology | News | Article

Lorlatinib benefits extend to NSCLC patients with brain metastases

Patients with advanced ALK-positive non-small-cell lung cancer derive prolonged progression-free survival from first-line treatment with lorlatinib regardless of the presence of brain metastases, post-hoc analyses indicate.

20-06-2022 | Rheumatology | News | Article

Predictors of complete remission in SLE identified

Research has revealed factors associated with complete remission in patients with systemic lupus erythematosus, including lack of renal involvement and antiphospholipid syndrome, White ethnicity, and older age at diagnosis.

17-06-2022 | Diabetes | News | Article

‘Reverse dipping’ forecasts long-term mortality in people with diabetes

Having blood pressure that is higher at night than during the day is associated with an increased mortality risk in people with diabetes, shows a 21-year study.

17-06-2022 | Diabetes | News | Article

Diabetes hastens progression of preclinical heart failure

The presence of diabetes in people with preclinical heart failure shortens the time to a first clinical event, especially if blood glucose is poorly controlled, show data from the ARIC study.

17-06-2022 | Rheumatology | News | Article

Walking for exercise ‘should be encouraged’ in people with knee osteoarthritis

Findings from an observational study suggest that walking for exercise is associated with a reduced risk for developing frequent knee pain among people aged 50 years and older with knee osteoarthritis.

17-06-2022 | Oncology | News | Article

CheckMate 9ER update confirms first-line nivolumab plus cabozantinib benefits for advanced RCC

The latest findings from the CheckMate 9ER trial show that the combination of nivolumab plus cabozantinib continues to offer superior survival to that of sunitinib for patients with treatment-naïve advanced renal cell carcinoma after a median follow-up of 32.9 months.

16-06-2022 | Oncology | News | Article

Mammogram method choice should consider breast density, cancer risk

Women with extremely dense breasts and a high breast cancer risk have a lower risk for advanced cancer when screened by digital breast tomosynthesis than digital mammography, US study findings indicate.

16-06-2022 | Rheumatology | News | Article

Targeted therapy not linked to serious infection risk in older people with RA

Older people with rheumatoid arthritis are not at increased risk for hospitalization with infection when receiving targeted therapy with biologics or JAK inhibitors rather than methotrexate, Japanese researchers report.