The presence of mild cognitive impairment, orthostatic hypotension, and rapid eye movement sleep behaviour disorder may identify a subset of Parkinson’s disease patients with a poor prognosis, research suggests.
Deep-brain stimulation targeting the subthalamic nucleus with a multiple-source constant-current device effectively suppresses motor symptoms in patients with advanced Parkinson’s disease, report researchers.
The presence of impulse control disorders is associated with reduced resting-state connectivity between part of the associative striatum and both associative and limbic cortical regions in patients with Parkinson’s disease, a study suggests.
Deep-brain stimulation of the subthalamic nucleus may improve motor symptoms in patients with Parkinson’s disease by reducing excessive cortical phase–amplitude coupling, researchers report in Nature Neuroscience.
Subthalamic nucleus deep brain stimulation has a beneficial effect on pain severity in patients with Parkinson’s disease that persists for up to 8 years, say researchers, but new onset of musculoskeletal pain in many suggests its effects are not enduring.
Neuropsychiatric symptoms, but not cognitive impairment, are common in early untreated patients with Parkinson’s disease, suggest findings from the multicentre Parkinson’s Progression Markers Initiative.
Using both enlarged substantia nigra hyperechogenicity and hyposmia for diagnosing Parkinson’s disease greatly enhances the specificity, research shows, but lowers the sensitivity compared with either marker on its own.