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Parkinson's disease

Parkinson's disease

18-06-2015 | Parkinson's disease | News | Article

Nonmotor features may predict PD progression

The presence of mild cognitive impairment, orthostatic hypotension, and rapid eye movement sleep behaviour disorder may identify a subset of Parkinson’s disease patients with a poor prognosis, research suggests.

12-06-2015 | Parkinson's disease | News | Article

α-synuclein conformation may underlie neurodegenerative variability

Varying structural conformations of α-synuclein may explain how one protein can give rise to distinct forms of neurodegeneration, say researchers.


11-06-2015 | Parkinson's disease | News | Article

Promising results for multi-source DBS in Parkinson’s disease

Deep-brain stimulation targeting the subthalamic nucleus with a multiple-source constant-current device effectively suppresses motor symptoms in patients with advanced Parkinson’s disease, report researchers.

05-06-2015 | Parkinson's disease | News | Article

Severe nonmotor symptom burden common in early Parkinson’s

Almost all patients with early Parkinson’s disease have nonmotor symptoms, with more than a third having a severe burden of symptoms, a study shows.

05-06-2015 | Parkinson's disease | News | Article

Resting-state connectivity changes underpinning ICDs identified

The presence of impulse control disorders is associated with reduced resting-state connectivity between part of the associative striatum and both associative and limbic cortical regions in patients with Parkinson’s disease, a study suggests.

04-06-2015 | Parkinson's disease | News | Article

Gender influences nonmotor symptoms in early Parkinson’s

The predominant nonmotor symptoms in patients with Parkinson’s disease vary between men and women, shows an analysis of the Parkinson’s Progression Markers Initiative study.

08-05-2015 | Parkinson's disease | News | Article

β-amyloid deposition highly variable in synucleinopathy

A meta-analysis suggests large variability in the prevalence of β-amyloid deposition in patients with synucleinopathies.

08-05-2015 | Parkinson's disease | News | Article

RBD persists in Parkinson’s disease patients

Symptoms of rapid eye movement sleep behaviour disorder are unlikely to resolve in patients with Parkinson’s disease, show the findings of a 3-year study.

08-05-2015 | Parkinson's disease | News | Article

Olfactory bulb changes fall short as imaging marker for PD

Functional and histopathological changes in the olfactory bulb in patients with Parkinson’s disease do not equate to a volume change that is detectable on magnetic resonance imaging, say researchers.


13-04-2015 | Parkinson's disease | News | Article

Brain activity changes underlying DBS success in parkinsonism pinpointed

Deep-brain stimulation of the subthalamic nucleus may improve motor symptoms in patients with Parkinson’s disease by reducing excessive cortical phase–amplitude coupling, researchers report in Nature Neuroscience.

07-04-2015 | Parkinson's disease | Article

Impulse control disorders do not promote cognitive decline in PD

Impulse control disorders in patients with Parkinson’s disease are not associated with more marked impairment of cognitive function, researchers report.

07-04-2015 | Parkinson's disease | Article

Deep brain stimulation reduces PD pain severity but does not prevent it

Subthalamic nucleus deep brain stimulation has a beneficial effect on pain severity in patients with Parkinson’s disease that persists for up to 8 years, say researchers, but new onset of musculoskeletal pain in many suggests its effects are not enduring.

07-04-2015 | Parkinson's disease | Article

Bilirubin levels raised in newly diagnosed Parkinson’s disease

Bilirubin levels are upregulated in patients with early Parkinson’s disease and are associated with disease progression at 2 years, a study shows.

07-04-2015 | Parkinson's disease | Article

Early neuropsychiatric symptoms prevalent in PD

Neuropsychiatric symptoms, but not cognitive impairment, are common in early untreated patients with Parkinson’s disease, suggest findings from the multicentre Parkinson’s Progression Markers Initiative.

17-03-2015 | Parkinson's disease | Article

Cumulative genetic risk may underlie many Parkinson’s cases

Genetic risk for Parkinson’s disease may be due as much to multiple genes with small individual effects as to single high-risk genes, research suggests.

05-03-2015 | Parkinson's disease | Article

Serotonergic denervation not responsible for levodopa-induced dyskinesia

Researchers find no differences in serotonergic markers between Parkinson’s disease patients who do and do not develop levodopa-induced dyskinesia.

03-03-2015 | Parkinson's disease | Article

Markers refine Parkinson’s risk in REM sleep behaviour disorder patients

Predictive markers can identify patients with REM sleep behaviour disorder who have a very high short-term risk of developing parkinsonism or dementia, research suggests.

27-02-2015 | Parkinson's disease | Article

Self-assessment may mislead on impulse control in Parkinson’s patients

Researchers report “striking” discrepancies between the rates of impulse control disorders reported in patients with Parkinson’s disease by self-assessment and by their caregivers.

27-02-2015 | Parkinson's disease | Article

Combining markers increases specificity, reduces sensitivity for PD diagnosis

Using both enlarged substantia nigra hyperechogenicity and hyposmia for diagnosing Parkinson’s disease greatly enhances the specificity, research shows, but lowers the sensitivity compared with either marker on its own.

26-02-2015 | Parkinson's disease | Article

Colonic mucosal α-synuclein ruled out as Parkinson’s biomarker

Aggregated and hyperphosphorylated α-synuclein are present as frequently in the colonic mucosa of healthy people as they are in that of patients with Parkinson’s disease, a study shows.