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Paediatric endocrinology

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Visit our dedicated microsite for research news, interviews and in-depth analysis of paediatric endocrinology and growth disorders.

  • Three risk factors for CAH hospitalisation identified

  • Endocrine Society publishes paediatric obesity management guidelines

Pulmonary hypertension

06-03-2017 | Pulmonary hypertension | News | Article

Systemic sclerosis associated with poor survival in CTD-PAH

A Chinese cohort study identifies factors associated with prognosis among patients with connective tissue disease-associated pulmonary arterial hypertension.

03-03-2017 | Pulmonary hypertension | News | Article

Right atrial strain associated with clinical outcomes in PAH

Study results suggest that right atrial strain could predict adverse outcomes among patients with pulmonary arterial hypertension.

10-02-2017 | Pulmonary hypertension | News | Article

Post-treatment pulmonary arterial compliance best predicts PAH prognosis

Evaluation of pulmonary arterial compliance after initiation or escalation of therapy for pulmonary arterial hypertension more accurately predicts prognosis than conventional right heart hemodynamic parameters, Italian study findings indicate.

HBV

10-02-2017 | HBV | News | Article

Liver fibrosis steadily increases in untreated HBV with stable viral load

Liver fibrosis, estimated using the Fibrosis-4 index, increases significantly over time in untreated patients with hepatitis B infection, despite viral loads remaining largely stable, US researchers report.

09-02-2017 | HBV | News | Article

IFN-λ3 induction shows potential as anti-HBV therapy

Early research from Japan suggests that induction of interferon-λ3 could be a promising therapeutic strategy in patients with hepatitis B virus infection.

09-02-2017 | HBV | News | Article

Albumin–bilirubin score predicts HBV-related cirrhosis survival

Research shows that the albumin–bilirubin score is a significant determinant of the long-term prognosis of patients with hepatitis B virus-associated cirrhosis, outplaying both the Child–Pugh and model for end-stage liver disease scores for this purpose.

Asthma

20-03-2017 | Asthma | News | Article

Th2 molecular phenotypes defined for severe asthma

Researchers have defined three molecular phenotypes of asthma, based on T-helper cell type 2 status, which could help better target specific treatments.

13-02-2017 | Asthma | News | Article

Eosinophilic airway inflammation and microbiome link

Eosinophilic airway inflammation in patients with asthma is associated with an altered microbiome in the lower airway, report researchers.

13-02-2017 | Asthma | News | Article

Biomarkers aid Type-2 inflammation phenotype selection

Researchers have identified a panel of clinically accessible biomarkers that may help select asthma patients with an airway-mucosal T-helper 2 inflammation phenotype.

Rheumatology

27-03-2017 | Rheumatology | News | Article

Rituximab falls short in Sjögren's syndrome trial

Treatment with two courses of rituximab does not reduce fatigue or oral dryness among patients with primary Sjögren's syndrome, results of the TRACTISS trial suggest.

24-03-2017 | Rheumatology | News | Article

Adalimumab discontinuation ‘feasible’ in early RA patients

The majority of patients with early rheumatoid arthritis maintain low disease activity for up to 3 years after discontinuing adalimumab therapy, Japanese researchers report.

02-02-2017 | Pulmonary hypertension | News | Article

Ambrisentan–tadalafil combination beneficial in CTD-associated PAH

A post-hoc subgroup analysis of the AMBITION trial suggests that the benefits of ambrisentan and tadalafil combination therapy extend to patients with connective tissue disease-associated pulmonary arterial hypertension.

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