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06-10-2009 | Oncology | Article

Diet impact on prostate cancer risk, survivorship under examination


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MedWire News: Results from men participating in the UK’s ProtecT trial may help determine the significance of diet in prostate cancer risk and survivorship.

Researchers presented information on two ongoing studies at the National Cancer Research Institute conference in Birmingham, UK.

The ProtecT trial is a multicenter randomized controlled trial examining the efficacy and acceptability of clinically localized prostate cancer in unselected men aged 50–69 years invited to undergo prostate cancer screening.

Catherine Jameson (University of Bristol) and colleagues asked 64,186 men on recruitment to complete food frequency questionnaires (FFQs) and 1-week diet diaries detailing content and portion size using photographic aids.

The team has collected detailed 1-week diaries from 37,189 participants (58% response rate) and FFQs from 41,965 participants (65% response rate).

The information is now being examined on a case–control basis, with data analysis planned for 2009 and 2010. Speaking to MedWire News, Jameson noted that, although diet diaries are more labor intensive than FFQs, they provide a more accurate picture of the patient’s diet.

Jameson et al hope that their findings will provide a “unique opportunity to provide insight into the etiology of prostate cancer.”

In a second study, Kerry Avery (University of Bristol, UK) and co-workers have begun investigating the impact of diet and nutritional supplements on men aged 50–69 years who have been diagnosed with prostate cancer.

Co-author J Athene Lane explained to MedWire News that patients participating in the primary care-based ProtecT trial of prostate cancer testing and treatment often reported changing their diet or use of supplements after diagnosis.

To characterize these behaviors, 1000 men with prostate cancer or at risk for the disease have completed a questionnaire on the factors that have influenced any dietary changes.

Sixty men will also be interviewed on their prostate cancer knowledge, dietary decisions, and their partners’ roles in any changes, and the team plans to hold focus groups with patients, partners, and health professionals to determine their preferred dietary advice.

The findings will be combined with a systematic review of nutritional intervention and behavioral changes in prostate cancer patients.

“A package of best evidence will be produced for the National Health Service of dietary advice for men with/at risk for prostate cancer,” the team concluded.

MedWire ( is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2009

By Lynda Williams

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