Thyroid function linked to cancer risk
medwireNews: Elevated levels of free thyroxine (FT4) are associated with an increased risk of developing cancer.
Among 10,318 participants of the Rotterdam Study with available baseline FT4 measurements, the risk of any solid cancer was elevated a significant 1.42-fold for every 1 ng/dL increase in FT4 levels after accounting for multiple confounders. The risk of developing lung or breast cancer was also increased, at a significant 2.33- and 1.77-fold, respectively.
Researcher Bruno Stricker (Erasmus University Medical Center, Rotterdam, the Netherlands) and collaborators note that the risk estimates remained similar after adjusting for use of thyroid-function altering medication, but the association with breast cancer lost statistical significance.
The team concludes in The Journal of Clinical Endocrinology & Metabolism that “[f]uture studies are needed to further elucidate the possible role of thyroid function in the pathogenesis of cancer”.
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