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17-04-2019 | Diabetes | News | Article

SONAR results support atrasentan for preserving renal function in type 2 diabetes

The endothelin receptor antagonist atrasentan may reduce the risk for kidney disease progression among certain high-risk patients with type 2 diabetes and kidney disease, indicate findings from the SONAR trial.

09-08-2016 | Diabetes | News | Article

Steady prevalence masks changes in diabetic kidney disease

Patients with diabetic kidney disease have become less likely to have albuminuria but more likely to have a reduced estimated glomerular filtration rate over recent years, shows an analysis of NHANES data.

16-06-2016 | Arrhythmia | News | Article

Worsening renal function linked to increased cardiovascular risk in AF

Patients with atrial fibrillation and declining renal function are at increased risk of subsequent stroke or systemic embolism, major bleeding and death, US researchers report.

15-06-2016 | Diabetes | News | Article

Empagliflozin offers long-term renal protection in Type 2 diabetes

The sodium–glucose cotransporter 2 inhibitor empagliflozin slows renal progression and averts clinical events, shows further analysis of the EMPA-REG OUTCOME trial.

01-06-2016 | Stroke | News | Article

Researchers call for more accurate renal assessment in stroke patients

Unrecognised renal insufficiency is common among patients with acute stroke and is associated with a significantly increased risk of in-hospital mortality or severe disability at discharge, say researchers.

31-05-2016 | Diabetes | News | Article

Renal function trajectories predict CV events in diabetes patients

Steeper declines in renal function over time are associated with greater increases in the risk of major cardiovascular events among patients with Type 2 diabetes, research shows.

26-05-2016 | Acute coronary syndromes | News | Article

CKD status does not affect health status outcomes after AMI

Chronic kidney disease does not accentuate the decline in health status often experienced by patients after acute myocardial infarction, US study data show.

25-05-2016 | Cardiology | News | Article

Sodium excretion linked to CVD risk in chronic kidney disease

High levels of sodium excretion are associated with a significantly increased risk of cardiovascular disease in patients with chronic kidney disease (CKD), US study findings indicate.

10-03-2016 | HBV | News | Article

Renal risk factors for NA-treated HBV patients identified

A South Korean research team has identified several clinical and medical factors associated with renal function decline in patients with chronic hepatitis B virus infection treated with oral nucleos(t)ide analogues.

15-12-2014 | Oncology | Article

RCC renal function independent of axitinib-induced proteinuria

Treatment with the vascular endothelial growth factor receptor inhibitor axitinib does not adversely affect renal function in patients with metastatic renal cell carcinoma even in the presence of proteinuria, a Japanese study indicates.

15-12-2014 | Oncology | Article

Metastatic RCC patients may benefit from sequential TKI strategy

For patients with metastatic renal cell carcinoma, sequential tyrosine kinase inhibitor therapy may be better option than changing to a mammalian target of rapamycin inhibitor, research suggests.

17-11-2014 | Oncology | Article

Nonlinear correlation between axitinib dose, dBP increase

A pharmacokinetic–pharmacodynamic model shows that diastolic blood pressure rises with increasing doses of axitinib in patients with metastatic renal cell carcinoma, US researchers report, although this relationship is not linear.

17-11-2014 | Oncology | Article

Statin use linked to improved RCC surgery outcomes

Statin use at the time of surgery is associated with improved overall survival and disease-specific survival in patients with renal cell carcinoma of any stage, US researchers report.

12-11-2014 | Oncology | Article

Cytoreductive nephrectomy benefits limited by preoperative risk factors

The survival benefit of cytoreductive nephrectomy when used in conjunction with targeted therapy for metastatic renal cell carcinoma depends on the number of preoperative risk factors a patient carries, study findings indicate.

26-10-2014 | Oncology | Article

TNF-α key player in RCC progression

Tumour necrosis factor - α appears to play a key role in the promotion of invasion and metastasis in clear cell renal cell carcinomas, Japanese study findings indicate.

26-10-2014 | Oncology | Article

Insufficient Th1 polarisation blocks RCC vaccine efficacy

A lack of a clinical response to an allogenic gene-modified renal cell cancer vaccine may be due to insufficient type 1 T-helper cell polarisation, show results of a gene expression profiling study.

26-10-2014 | Oncology | Article

Partial nephrectomy efficacious for clinical T2 renal masses

Survival outcomes and overall complication rates of partial nephrectomy for clinical T2 renal masses are comparable to those of radical nephrectomy when the pathological staging, histology and grading of the tumours are similar, researchers report.

26-10-2014 | Oncology | Article

Laparoscopic renal cyroablation effective for small RCCs

Study findings support the primary use of laparoscopic renal cryoablation for long-term disease control in patients with a newly diagnosed single clinical T1a small renal mass.

22-09-2014 | Oncology | Article

Guidelines for management of small renal masses questioned

Partial nephrectomy and percutaneous ablation for small and localised renal masses produce similar rates of local tumour recurrence, report US researchers.

21-09-2014 | Oncology | Article

Immature blood vessels linked to poor sunitinib response

Patients with clear-cell renal cell carcinoma with relatively mature blood vessels respond better to sunitinib and have fewer metastatic sites than those with immature vessels, a study has found.

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