Perceived negative attitude predicts psychosis transition
MedWire News: A perceived negative attitude of others to oneself predicts transition to full-blown psychosis in patients at risk for the mental health disorder, study results show.
The findings suggest that among individuals at increased risk for psychosis "early screening and early detection of a patient's negative appraisals of others' attitude combined with a treatment strategy focusing on this particular symptom would appear to be warranted," say the authors.
Raimo Salokangas (University of Turku, Finland) and team studied 55 patients (37 women), aged a mean of 22.6 years, who were at risk for psychosis due to transient, limited positive psychotic or psychotic-like (attenuated psychotic) symptoms, or a decline in functioning together with familial risk for psychosis.
All of the participants were assessed for prodromal symptoms at baseline using the PROD questionnaire, which includes a question on the attitude of other people toward oneself.
In total, eight (14.5%) patients made the transition to psychosis over a follow-up period of up to 59 months, with a median time to transition of 8.7 months.
The researchers found that four (57.1%) of the seven patients who reported a negative attitude of others at baseline made the transition to psychosis compared with four (8.7%) of the 46 patients who did not.
Multivariate Cox regression analysis revealed that a perceived negative attitude of others at baseline significantly predicted the transition to psychosis among the participants, at an odds ratio of 14.5.
Salokangas and colleagues conclude in European Psychiatry: "These results hold implications for future intervention strategies involving individuals identified as being at-risk of developing psychosis.
"Ascertaining the attitude they perceive that others hold towards them may help clinicians in identifying patients who are at an 'ultra-high' risk of developing psychosis."
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By Mark Cowen