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ASH 2018: Expert interviews

05-12-2018 | Leukaemia | Video

Quantum-R trial looks at efficacy of quizartinib in AML patients

Jorge Cortes outlines the findings from the Quantum-R trial of quizartinib in patients with relapsed/refractory acute myeloid leukaemia with a FLT3-internal tandem duplication and a poor prognosis (5:58).

04-12-2018 | Lymphoma | Video

Two-year follow-up and high-risk subset analysis of ZUMA-1

Frederick Locke discusses long-term follow-up results from the ZUMA-1 trial, demonstrating high rates of durable response to axicabtagene ciloleucel treatment among patients with refractory large B-cell lymphoma (4:28).

04-12-2018 | Oncology | Video

Prophylactic treatment with rivaroxaban reduces cancer patients' VTE risk

Study author Alok Khorana discusses the results of the CASSINI trial, demonstrating a reduction in venous thromboembolism during treatment with rivaroxaban among patients with cancer (2:54).

04-12-2018 | Leukaemia | Video

BCL2 gene mutation confers resistance to venetoclax treatment in CLL patients

Piers Blombery comments on his study results demonstrating that the BCL2 Gly101Val mutation impairs binding of venetoclax to BCL2, leading to an increased risk of chronic lymphocytic leukaemia progression during treatment (2:56).

04-12-2018 | Lymphoma | Video

Sustained disease control with tisagenlecleucel in refractory DLBCL setting

Richard Maziarz takes us through the long-term follow-up results of the JULIET trial indicating that the CAR T-cell therapy tisagenlecleucel has achieved a high response rate and enduring responses in adults with relapsed or refractory diffuse large B-cell lymphoma (6:38).

04-12-2018 | Lymphoma | Video

Reducing chemotherapy in younger diffuse large B-cell lymphoma patients

Viola Poeschel outlines findings from the FLYER trial, showing that a six-cycle R-CHOP plus rituximab regimen can be reduced to four cycles of R-CHOP plus rituximab without compromising efficacy in younger patients with diffuse large B-cell lymphoma and a favourable prognosis (4:33).

03-12-2018 | Chronic myeloid leukaemia | Video

EUTOS long-term survival score recommended over Sokal score for elderly CML patients

Presenting author Fausto Castagnetti discusses the results of their study assessing the best score to predict outcomes in older patients with chronic myeloid leukaemia (4:17).

ESMO 2018: Expert interviews

24-10-2018 | Head and neck cancer | Video

KEYNOTE-048: Phase III study of first-line pembrolizumab for recurrent/metastatic head and neck squamous cell carcinoma

Barbara Burtness talks through the results of the KEYNOTE-048 trial comparing pembrolizumab alone or with chemotherapy versus the EXTREME regimen for patients with recurrent or metastatic head and neck cancer (5:10).

24-10-2018 | Breast cancer | Video

PALOMA-3 defines a new standard of care for advanced breast cancer

Massimo Cristofanilli discusses the latest results from the PALOMA-3 trial investigating the addition of the CDK4/6 inhibitor palbociclib to fulvestrant in previously treated advanced breast cancer (5:21).

24-10-2018 | Head and neck cancer | Video

De-ESCALaTE HPV results revealed

Hisham Mehanna describes the results of the De-ESCALaTE HPV  trial comparing cetuximab versus cisplatin for the treatment of low-risk oropharyngeal cancer patients undergoing radiotherapy (5:43).

24-10-2018 | Breast cancer | Video

IMpassion130 survival results

Peter Schmid discusses the progression-free and interim overall survival results for atezolizumab plus nab-paclitaxel in the setting of metastatic triple-negative breast cancer (5:24).

ASCO 2018: Expert interviews

06-06-2018 | Genetics | Video

Matching treatment to molecular alterations in tumors has an IMPACT on survival

Apostolia Tsimberidou discusses the findings of the IMPACT study, looking at the survival benefits of matching targeted treatments to the genetic alterations of tumors across multiple cancer types (7:56).

05-06-2018 | Kidney cancer | Video

CARMENA trial of cytoreductive nephrectomy in renal cell carcinoma

Arnaud Méjean presents the CARMENA trial findings, suggesting that cytoreductive nephrectomy may no longer be the standard of care for metastatic renal cell carcinoma in the era of sunitinib (4:21).

05-06-2018 | Breast cancer | Video

TAILORx trial in breast cancer

Joseph Sparano gives an overview of his team's findings regarding a 21-gene prognostic test that could help tailor treatment for women with early breast cancer (3:24).

04-06-2018 | Prostate cancer | Video

Abi Race: abiraterone acetate and prednisone treatment in Black and White men with prostate cancer

Lead author Daniel George discusses his findings of a greater and longer lasting treatment effect with abiraterone acetate and prednisone in Black than White men with metastatic castration-resistance prostate cancer (3:59).

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