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21-12-2018 | Lung cancer | News | Article

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Lung cancer ctDNA sequencing allows timely initiation of targeted therapy

medwireNews: Digital next-generation sequencing (NGS) of circulating tumor (ct)DNA is a clinically useful option for advanced lung adenocarcinoma patients with insufficient tumor biopsy samples, say researchers.

They drew on a cohort of 93 patients from 12 Spanish institutions without sufficient tissue for genotyping, and found that 89% had detectable levels of ctDNA. Fifty-three (57%) individuals had potentially actionable genomic alterations, while 13 (14%) harbored alterations for which therapies approved by the US FDA or clinical practice guidelines were available.

ctDNA results were available at a median of 13 days from when the blood sample was obtained, and resulted in “timely initiation of genotype-matched therapies” in 12 patients, report Pilar Garrido (Hospital Universitario Ramon y Cajal, Madrid, Spain) and colleagues. The remaining patient experienced rapid clinical deterioration and was unable to receive targeted treatment.

“These results complement the findings from other studies using plasma-based NGS in patients with lung cancer, adding now further evidence to its utility to impact clinical care in a prospective, multicenter and clinically unselected cohort of patients without tumor tissue for molecular analysis,” the team concludes in the Annals of Oncology.

By Shreeya Nanda

medwireNews is an independent medical news service provided by Springer Healthcare. © 2018 Springer Healthcare part of the Springer Nature group